Volume 8, Issue 3 (10-2021)                   NBR 2021, 8(3): 173-182 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Garshasbi M, Divsalar A. Investigation of presence of folate on physicochemical and anticancer properties of beta-lactoglobulin nanocapsules against human colon cancer cell line of HTC116 . NBR 2021; 8 (3) :173-182
URL: http://nbr.khu.ac.ir/article-1-3424-en.html
Kharazmi University , divsalar@khu.ac.ir
Abstract:   (1726 Views)
Nanotechnology-based targeting drug delivery systems have a considerable potential in medicine. Therefore, the present study aimed to designe, synthesise and characterize a nanodrug with beta lactoglobulin coating including oxali-palladium with and without folate and to compare their anti-cancer effects. The physicochemical properties of nanocapsules were studied by Dynamic light scattering (DLS), atomic force microscopy (AFM) and scanning electron microscopy (SEM). Finally, the anticancer activities of nanodrugs were investigated against human colorectal cancer cell line of HCT116 by MTT and flowcytometry methods. The results of Dynamic light scattering (DLS), scanning electron microscopy (SEM) and atomic force microscopy (AFM) showed that the average size of nanocapsules with folate were less than 40 nm. Cytotoxicity results proved the dose- and time-dependent antiproliferation and anicancer activities of nanocapsules (with folate) against HCT116. Finally, it could be concluded that folate increase anticancer activity of nanodrugs and it might be considered as a new candidate in the design and synthesis of new drugs in cancer treatment.


 
Full-Text [PDF 334 kb]   (837 Downloads)    
Type of Study: Original Article | Subject: Cell and Molecular Biology
Received: 2020/11/20 | Revised: 2021/10/30 | Accepted: 2021/06/27 | Published: 2021/10/19 | ePublished: 2021/10/19

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons Licence
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.



© 2024 CC BY-NC 4.0 | Nova Biologica Reperta

Designed & Developed by : Yektaweb