Showing 2 results for Hippocampus
Neda Tanbaccochi Moghadami, Homira Hatami Nemati, Gholamreza Dehghan, Seyyed Mehdi Banan Khojast, Hatam Ahmadi,
Volume 7, Issue 2 (7-2020)
Abstract
Malathion is one of the commonest type of organophosphate insecticide whose toxicity in human body is mainly considered to result from the induction of oxidative stress. The aim of this study was to investigate the antioxidant effect of Quercetin, a flavonoid compound, on the spatial memory and oxidative stress parameters during Malathion poisoning in male Wistar rats. This study was performed on nine groups, each of which consisted of eight male rats. Three days after intra-peritoneal injection of Quercetin, Malathion or a combination of these two drugs, the Moris Water-Maze apparatus was used to measure spatial memory parameters. The hippocampus was sampled and the oxidative stress parameters were measured in this area. Intra-peritoneal injection of Malathion (100 and 200 mg/kg) significantly reduced spatial memory parameters (P<0.01) and induced oxidative stress (P<0.001), whereas intra-peritoneal injection of quercetin (50 mg/kg) improved spatial memory in Malathion-poisoned experimental rats (P<0.05). Also, oxidative stress parameters in Malathion-treated groups showed a significant reduction in quercetin treatment (P<0.01). Quercetin was observed to restore the function of spatial memory and the level of oxidative stress parameters of the treated groups with Malathion to the normal level.
Dr Akbar Hajizadeh Moghaddam, Mr Farhad Samei, Dr Sedigheh Khanjani Jelodar, Mrs Fatemeh Malekzadeh Estalkhi,
Volume 11, Issue 2 (8-2024)
Abstract
Long-term ethanol consumption leads to the destruction of neurons in the central nervous system and cells in the hippocampus by causing oxidative stress. Astaxanthin (ATX) is a carotenoid that serves as an antioxidant and anti-inflammatory agent. This study sought to examine the impacts of astaxanthin on learning and memory impairments and oxidative damage within the hippocampus of mice induced by ethanol. 35 mice were divided into five groups (n=7): the control group didn't receive any treatment. The positive control group received 20 mg/kg ATX. The ethanol group received 20% ethanol, and two ATX treatment groups received doses of 10 and 20 mg/kg, which first received 20% ethanol and then ATX. All treatments were done orally for 14 consecutive days. In this research, the novel object recognition test (NORT), malondialdehyde (MDA) and dopamine (DA) levels, and activities of catalase (CAT) and superoxide dismutase (SOD) were analyzed in the hippocampus of mice. Ethanol consumption decreased the discrimination index in NORT, activities of CAT and SOD, and increased the levels of DA and MDA, compared to the control group. ATX treatment led to an increase in the discrimination index in NORT, activities of CAT and SOD, and a decrease in the levels of DA and MDA, compared to the ethanol group. Results showed astaxanthin's antioxidant properties can improve ethanol-induced cognitive defects and oxidative damage. Therefore, astaxanthin can be used as a potential food and drug supplement to reduce ethanol-induced disorders.
