Zahra Sadat Mirei, Minoo Sadri, Ali Salimi,
Volume 3, Issue 3 (12-2016)
Abstract
Main agent orange-red coloured pigment of henna is a molecule called Lawson which is responsible for anti-microbial, anti-tumor, anti-inflammatory and analgesic activity. Chitosan is a biopolymer with high strength, biocom-patibility and biodegradability, non-toxicity and antimicrobial properties. Electrospinning is a method of producing su-bmicron polymeric fibers with high porosity and high surface/volume ratio. In this study, electrospinning of chitos-an/polyethylene oxide (Chit/PEO) nanofibers with the addition of henna extract to create nanofibers with antimicrobial properties were examined. Nanofibers was constructed by electrospinning of polymeric solution with proper size and si-ze distribution of Chit/PEO with a ratio 90/10. Then, Lawsonia inermis (henna) extract as an additive to Chit/PEO co-polymer was added and electrospined on the surface. After characterization of nanofibers using SEM, the antimicrobial properties of polymeric solution and nanofibers were investigated. The scanning electron micrographs showed that Ch-it/PEO nanofibres with a low percentage of henna extract have suitable diameters and size distribution similar to Ch-it/PEO nanofibres without adding extract. In bacteriological studies, it was found that chitosan polymer solutions cont-aining 1% of henna extract has bactericidal properties against Staphylococcus aureus, Escherichia coli and Pseudo-monas aeruginosa bacteries better than polymer chitosan solution without adding the extract.
Nina Alizadeh, Shokufeh Malakzadeh,
Volume 8, Issue 2 (7-2021)
Abstract
The aim of this study was to investigate the interaction modification of curcumin complex molecule (CUR) in beta- and gamma-cyclodextrin (β-CD and γ-CD) carriers with chitosan (CS) nanoparticles for targeted drug delivery and to compare their performance. The targeted drug delivery system includes the therapeutic agent of the CS nanoparticles targeting section of the same drug and the CD carrier system. Calculations of the relationships of the formation of modified complexes and their application were performed using UV-vis spectroscopic data analysis. In this study, spectroscopic spectrum diagrams were drawn to prove the optimization of molecular structure in the modified complexes. Data analysis was performed using their respective equations. The cationic polysaccharide CS, with the presence of amino agents and alcohols along the polysaccharide chains, enables it to form a covalent bond with the complexes and increase the solubility of cyclodextrin. CS nanoparticles strengthen the hydrogen bond by hydrogen bonding and van der Waals hydrogen interactions of the hydroxyl cyclodextrin group with the hydroxyl phenolic group of the drug molecule CUR. Modification of the γ-CD complex with CS shows the strongest interaction with CUR. Both CUR complexes are in the CD-CS host system to transfer the charge from the drug to the carrier and the therapeutic agent. CS nanoparticles have the property of targeted delivery systems for anticancer drugs because the CS external field can be used to direct the drug to specific target cells. The γ-CD-CS host system is the best host as a carrier and therapeutic agent for CUR due to its high solubility and strong interaction.
Dr Azam Salimi, Ali Abbasi, Dr Maryam Chavoushi Rizi,
Volume 11, Issue 4 (2-2025)
Abstract
Camelina (Cruciferae), is an oilseed. Chitosan is a natural biopolymer, non-toxic, and biocompatible which favors potentially broad application in biotic and abiotic stress. Iron is an essential micronutrient for almost all living organisms because it plays a critical role in metabolic processes respiration, and photosynthesis. In this research, examined the salinity (0, 8, 12, ds/m), (0, 5/12, 7/6 g/l) chitosan (0, 0.2, 0.4, g/l) and iron (0, 3, 6, g/l) based on a randomized block design with three replications. The sodium, root growth increased significantly in salinity. The irons and growth parameters decreased because the ionic ratio has been changed. Root increased to provide water. Due to the destructive effects of salinity, the increase of sodium has also affected other parameters and caused the decrease of iron and calcium. Stress has been reduced the shoot growth by affecting the growth of the plant. In this study, the interaction of salinity, chitosan, and iron, it was observed that the stem length, biomass, RWC, ions, carbohydrates increased and the root growth decreased. It has effect on RWC, regulating ions and compatible solutes, have been able to maintain the plant's conditions like stress-free conditions reduce the effects of salinity, and help plant growth.
Mahnaz Tymoori, Hussna Parvizi, , Mojtaba Koosha,
Volume 13, Issue 1 (4-2026)
Abstract
The aim of this study was to investigate the effect of cofactor-bearing chitosan-coated and non-chitosan carbon nanotubes on induction of apoptosis of cervical cancer HELAcell line by measuring the expression of Bax and Bcl-2 genes as well as cell growth and proliferation. MTT test was used for cell proliferation assay. Expression changes of Bax and Bcl-2 genes were analyzed by Real Time PCR. The MTT results showed that the carbon nanotube coated with caffeic acid carrier chitosan and without caffeic acid carrier and crude carbon nanotube and caffeic acid induce apoptosis and cell toxicity. The results showed that caffeic acid with a chitosan-coated carbon nanotube carrier increased Bax expression and decreased Bcl-2 gene expression, so that the expression ratio of Bcl-2 / Bax compared to free caffeic acid to significantly increase. The results show that the death of cancer cells treated with caffeic acid with chitosan-coated carbon nanotube carries an increase in Bcl-2 / Bax expression ratio and thus induces apoptosis in HELA cancer cells. . Also, the use of caffeic acid as a drug and carbon nanotube-coated carbon nanotube carriers of caffeic acid can be considered as a promising strategy in the treatment of cervical cancer.
