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Plants have been used as medicines in the treatment of diseases from the past to present. In this research, the anti-microbial effects of aqueous and methanolic extracts of Erythrostemon gilliesii were studied. For this purpose, fresh flowers were ground and then macerated in methanol 100% and water overnight. After the evaporation of solvents, anti-microbial activities of the concentrated extracts were evaluated by the well-diffusion method on Klebsiella pneumoniae, Pseudomonas aeroginosa, Methicilin resistance, Staphylococcus aureus, Bacillus subtilis and Candida albicans. The results showed that the extracts were effective on different bacteria and yeasts. In order to determine the minimum inhibitory concentration (MIC) and minimum biocidal concentration (MBC), anti-microbial tests were performed in micro-plates. Subsequently, the results indicated that the extracts were stable at different temperatures. The aqueous and methanolic extracts of the flowers of E. gilliesii had exhibited anti-microbial effects against important infectious microbes and could be introduced as an excellent source for anti-microbial agents.