Volume 11, Issue 3 (12-2024)                   nbr 2024, 11(3): 1-16 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

mavaddatiyan L, talkhabi M. Aging of mesenchymal stem cells: Investigating the role of ferroptosis using bioinformatics analyses. nbr 2024; 11 (3) : 1
URL: http://nbr.khu.ac.ir/article-1-3683-en.html
Shahid Beheshti University , mahmoodlt@yahoo.com
Abstract:   (228 Views)
Ferroptosis, as a type of newly recognized iron-dependent programmed cell death, is closely related to aging. The aim of this study is to investigate the role of ferroptosis in the aging of mesenchymal stem cells (MSCs). GSE97311 dataset (containing expression data of fetal and adult MSCs) was analyzed and differentially expressed genes (DEGs) were extracted. Then, among them, ferroptosis-related differentially expressed genes (FRDEGs) were determined. In the next step, biological functions, protein-protein interactions, hub genes, upstream regulators, and inflammatory factors related to FRDEGs were analyzed using different bioinformatics methods. According to the analysis, 34 genes were identified as FRDEGs. Analysis of biological functions showed that these genes are mostly involved in oxidoreductase activities, fatty acid synthesis and response to iron ion. Also, the analyzes related to the signaling pathways also showed that these genes are mostly involved in the pathways related to types of cancers as well as fatty acid biosynthesis. According to the analysis, miR-26b-5p was identified as the most important miRNA and LINC00205 and GAS5 as the most important lncRNAs. Hub genes including HMOX1, EZH2, NEDD4L, PTGS2, CDKN2A, ATF3, NOX4, TXNIP, SNCA and MAPK3 were identified as the main genes of ferroptosis related to aging of MSCs. 
Article number: 1
Full-Text [PDF 2461 kb]   (7 Downloads)    
Type of Study: Original Article | Subject: Cell and Molecular Biology
Received: 2024/06/15 | Revised: 2024/12/21 | Accepted: 2024/12/1 | Published: 2024/12/17 | ePublished: 2024/12/17

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons Licence
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.



© 2024 CC BY-NC 4.0 | Nova Biologica Reperta

Designed & Developed by : Yektaweb