Examining adaptation in the response of stimulatory and inhibitory genes of angiogenesis after resistance exercise intervention in older adults men

karami, Sajad; Rajabi, Hamid; Shahidi, Fereshteh; Golab, Fereshteh

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Examining adaptation in the response of stimulatory and inhibitory genes of angiogenesis after resistance exercise intervention in older adults men

Sajad Karami

, Hamid Rajabi

, Fereshteh Shahidi

, Fereshteh Golab

Shahid Rajaee University of Tehran , karami.sp@gmail.com

Abstract: (3901 Views)

Introduction and purpose: Age-related changes in the expression of angiogenesis-stimulating and inhibitory genes are characteristics of aging and endothelial dysfunction. Aerobic exercise can stop or reduce this disorder. Considering the importance of resistance training in the rehabilitation of the elderly, the aim of this study was to investigate the compatibility of the response of the stimulating and inhibiting factors of angiogenesis after resistance exercise intervention in the elderly. Methodology: 24 elderly men with an average age of 67.75 years were selected in an accessible and purposeful manner. Blood samples were taken before and after a resistance activity session before and after 8 weeks of resistance training. Real Time PCR method was used to express HIF-1, VEGF, SDF-1 and VEGI genes in blood tissue. The difference in the values of the variables was evaluated by the method of analysis of variance with repeated measurement of mixed design at the level of P≤0.05 using SPSS software version 25. Findings: HIF-1, VEGF and SDF-1 gene expression levels of the training group increased in the stages of the primary post-test (after one session), secondary pre-test and secondary post-test (after 8 weeks of training) and VEGI had no gene expression. Discussion and conclusion: It can be cautiously said that although one session of resistance training leads to gene expression of angiogenesis factors, long-term resistance training with sufficient intensity and volume can It activates the rate of angiogenesis in a much wider range and should be considered as a supplement to aerobic exercises in old age.

Keywords: Hypoxia inducing factor-1, vascular endothelial growth factor, stromal cell-derived factor-1, vascular endothelial growth inhibitory factor, resistance training, older adults’ men