Investigating The Effect Of Endurance Training as a Therapeutic Method On Muscle Cachexia and Cardiovascular Consequences caused by Breast Cancer

Shahabpoor, Elham; Delavari, Mohammad Amin

Volume 21, Issue 26 (12-2023) RSMT 2023, 21(26): 77-88 | Back to browse issues page

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Shahabpoor E, Delavari M A. Investigating The Effect Of Endurance Training as a Therapeutic Method On Muscle Cachexia and Cardiovascular Consequences caused by Breast Cancer. RSMT 2023; 21 (26) :77-88
URL: http://jsmt.khu.ac.ir/article-1-606-en.html

Investigating The Effect Of Endurance Training as a Therapeutic Method On Muscle Cachexia and Cardiovascular Consequences caused by Breast Cancer

Elham Shahabpoor ^*

, Mohammad Amin Delavari

Assistant Professor of exercise Physiology, Department of Sports Sciences, University of Hormozgan, Iran. , e.shahabpour@hormozgan.ac.ir

Abstract: (956 Views)

Cachexia syndrome and the risk of cardiovascular diseases are highly prevalent in cancer patients.The purpose of the present study was to investigate the effect of endurance training as a therapeutic method on muscle cachexia and cardiovascular consequences caused by breast cancer. After 2 weeks of breast cancer induction, 20 BALB/c mice (age: 6-8 weeks and weight: 17- 18 g) mice performed the maximum aerobic capacity test and were randomly allocated into tumor-control and tumor-exercise groups. The tumor-exercise group performed the endurance Training protocol for 6 weeks, 5 days a week with gradual increase in intensity from 12 to 20 (m.min-1) and duration from 25 to 55 minutes And 24 hours after the last training session, the maximum aerobic capacity test was performed. 48 hours after the last training session, the mice were sacrificed. Heart weight, weight of gastrocnemius and soleus muscle, heart mass index, ratio of weight of soleus muscle to body weight and ratio of weight of gastrocnemius muscle to body weight were measured in tumor-control and tumor-exercise groups. Data were analyzed by independent t-test at the significance level of P≥0.05. The results of the present study showed a significant increase in heart weight (P=0.005), spleen weight (P=0.029), weight of the gastrocnemius muscle (P=0.009) and soleus muscle (P=0.022) in the tumor-exercise group compared to the tumor-control group. Also, significant increase in the heart mass index (P=0.016) and the ratio of the weight of the gastrocnemius muscle to the body weight (P=0.005) and the ratio of the soleus muscle to the body weight (P=0.021) were observed in the tumor-exercise group compared to the tumor-control group. In conclusion,Endurance training seems to be a potential treatment method and strategy to improve the health of the skeletal muscle and cardiovascular system and reduce the process of muscle cachexia caused by breast cancer.

Keywords: Endurance Training, Cachexia, Cardiovascular Disease, Breast Cancer.

Full-Text [PDF 1891 kb] (76 Downloads)

Type of Study: Research | Subject: sport physiology
Received: 2023/08/8 | Accepted: 2023/11/14 | Published: 2023/12/31

References

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33. Kontomanolis EN, Kalagasidou S, Pouliliou S, Anthoulaki X, Georgiou N, Papamanolis V, Fasoulakis ZN. The notch pathway in breast cancer progression. The Scientific World Journal. 2018 Oct;2018. [DOI:10.1155/2018/2415489]

34. Mo H, Jazieh KA, Brinzevich D, Abraham J. A review of treatment-induced pulmonary toxicity in breast cancer. Clinical Breast Cancer. 2022 Jan 1;22(1):1-9. [DOI:10.1016/j.clbc.2021.05.014]

35. Perez IE, Taveras Alam S, Hernandez GA, Sancassani R. Cancer therapy-related cardiac dysfunction: an overview for the clinician. Clinical Medicine Insights: Cardiology. 2019 Jul;13:1179546819866445. [DOI:10.1177/1179546819866445]

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42. Helmark IC, Mikkelsen UR, Børglum J, Rothe A, Petersen MC, Andersen O, Langberg H, Kjaer M. Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. Arthritis research & therapy. 2010 Aug;12:1-1. [DOI:10.1186/ar3064]

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58. Gerritsen JK, Vincent AJ. Exercise improves quality of life in patients with cancer: a systematic review and meta-analysis of randomised controlled trials. British Journal of Sports Medicine. 2015 Dec 30. [DOI:10.1136/bjsports-2015-094787]

59. Winters-Stone KM, Bennett JA, Nail L, Schwartz A. Strength, physical activity, and age predict fatigue in older breast cancer survivors. InOncology nursing forum 2008 Sep 1 (Vol. 35, No. 5). [DOI:10.1188/08.ONF.815-821]

60. Beaudry RI, Kirkham AA, Thompson RB, Grenier JG, Mackey JR, Haykowsky MJ. Exercise Intolerance in Anthracycline‐Treated Breast Cancer Survivors: The Role of Skeletal Muscle Bioenergetics, Oxygenation, and Composition. The Oncologist. 2020 May 1;25(5):e852-60 . [DOI:10.1634/theoncologist.2019-0777]

61. Atella V, Piano Mortari A, Kopinska J, Belotti F, Lapi F, Cricelli C, Fontana L. Trends in age‐related disease burden and healthcare utilization. Aging cell. 2019 Feb;18(1):e12861. [DOI:10.1111/acel.12861]

62. Butt Z, Rosenbloom SK, Abernethy AP, Beaumont JL, Paul D, Hampton D, Jacobsen PB, Syrjala KL, Von Roenn JH, Cella D. Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy. Journal of the National Comprehensive Cancer Network. 2008 May 1;6(5):448-55. [DOI:10.6004/jnccn.2008.0036]