The Effect Of Swimming Aerobic Training On The Levels Of IL-6 And IL-10 In The Brain Tissue Of Female Mice With Experimental Autoimmune Encephalomyelitis

Ahmadi, Elmira; Shahrbanian, Shahnaz; Kordi, Mohamadreza; Gharakhanlou, Reza; Pearcey, Gregory

doi:10.61186/jsmt.22.27.55

Volume 22, Issue 27 (8-2024) RSMT 2024, 22(27): 55-74 | Back to browse issues page

‎ 10.61186/jsmt.22.27.55

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Ahmadi E, Shahrbanian S, Kordi M, Gharakhanlou R, Pearcey G. The Effect Of Swimming Aerobic Training On The Levels Of IL-6 And IL-10 In The Brain Tissue Of Female Mice With Experimental Autoimmune Encephalomyelitis. RSMT 2024; 22 (27) :55-74
URL: http://jsmt.khu.ac.ir/article-1-605-en.html

The Effect Of Swimming Aerobic Training On The Levels Of IL-6 And IL-10 In The Brain Tissue Of Female Mice With Experimental Autoimmune Encephalomyelitis

Elmira Ahmadi

, Shahnaz Shahrbanian

, Mohamadreza Kordi

, Reza Gharakhanlou

, Gregory Pearcey

Associate professor, Department of Sport Science, Faculty of Humanities, Tarbiat Modares University , sh.shahrbanian@modares.ac.ir

Abstract: (3574 Views)

Fatigue is one of the most common symptoms among individuals with multiple sclerosis (MS). The imbalance of inflammatory cytokines in the brain causes mental fatigue. It is believed that aerobic exercise may moderate the level of inflammation of cytokines and thus reduce mental fatigue. This study was conducted to investigate the effect of swimming aerobic training on pro-inflammatory factors (interleukin 6) and anti-inflammatory factors (interleukin 10) to evaluate mental fatigue in the brains of female mice after EAE induction. In this research, 21 mice (8 weeks old, 18 to 20 grams) were divided into three groups: healthy control, EAE control, and EAE swimming aerobic exercise. The animals in the training group performed moderate-intensity swimming exercises for 4 weeks, with 5 sessions per week, each session lasting 30 minutes. The western blot method was used to analyze the research variables. The results showed no significant difference in the amount of IL-6 between the EAE group and the swimming training group, but the amount of IL-10 in the swimming training group showed a significant increase compared to the EAE group. The ratio of IL-10/IL-6 values between the swimming training group and the EAE group was also not significant. It seems that moderate-intensity swimming aerobic exercises, without changing the pro-inflammatory factor, along with increasing the anti-inflammatory factor IL-10, can lead to an improvement in the balance of the inflammatory index and a reduction in fatigue in the EAE group and the swimming exercise group.

Keywords: Aerobic exercise, Interleukins, Inflammation, MS disease, Cytokines, Mental Fatigue.

Full-Text [PDF 675 kb] (308 Downloads)

Type of Study: Applicable | Subject: sport physiology
Received: 2023/06/6 | Accepted: 2024/01/3 | Published: 2024/08/31

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