The Effect of Aerobic Exercise and Quercetin Supplementation on Myostatin and Follistatin Levels in the Heart Tissue of Rats with Type 2 Diabetes

Soltani, Mohsen; Barzegari, Ali; Naghibi, Saeed; Dashty khavidaki, Mohammad hassaan

Volume 21, Issue 26 (12-2023) RSMT 2023, 21(26): 1-17 | Back to browse issues page

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Soltani M, Barzegari A, Naghibi S, Dashty khavidaki M H. The Effect of Aerobic Exercise and Quercetin Supplementation on Myostatin and Follistatin Levels in the Heart Tissue of Rats with Type 2 Diabetes. RSMT 2023; 21 (26) :1-17
URL: http://jsmt.khu.ac.ir/article-1-528-en.html

The Effect of Aerobic Exercise and Quercetin Supplementation on Myostatin and Follistatin Levels in the Heart Tissue of Rats with Type 2 Diabetes

Mohsen Soltani

, Ali Barzegari ^*

, Saeed Naghibi

, Mohammad hassaan Dashty khavidaki

Payame Noor University , ali_barzegari@pnu.ac.ir

Abstract: (1514 Views)

This study aimed to investigate the effect of quercetin supplementation and training on myostatin and follistatin levels in the heart tissue of diabetic rats. Methods: For this purpose, 50 10-week-old male Wistar rats with an average weight of 237±33 grams were randomly divided into five groups of 10 including: healthy control, diabetes, diabetes+supplement, diabetes+exercise, and diabetes+supplement+exercise. . The training protocol includes five sessions per week for eight weeks on a treadmill without a special slope. The rodents ran for 60 minutes at a speed of 25 meters per minute in each session.and the supplement groups received 50 mg/kg quercetin daily by gavage. The results showed that the difference in myostatin levels among the groups is significant (P=0.001). There was a significant decrease in myostatin levels between exercise+supplement+diabetes group with diabetes (P=0.002). There was also a significant difference between the supplement+diabetes and exercise+diabetes groups (P=0.009). Also, the results showed that the difference in follistatin levels among the groups is significant (P=0.001). The results showed that follistatin levels in the heart tissue increased significantly between the groups of diabetes, exercise+diabetes, supplement+diabetes and exercise+supplements+diabetes with the control group (respectively: P=0.005; P=0.001; P=0.001; P = 0.001).
It seems that moderate intensity aerobic exercise and quercetin supplementation have a positive and beneficial effect on the levels of myostatin and folstatin.

Keywords: Exercise, Diabetes, Follistatin, Myostatin

Full-Text [PDF 2209 kb] (108 Downloads)

Type of Study: Research | Subject: sport physiology
Received: 2022/04/14 | Accepted: 2023/05/29 | Published: 2023/12/31

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