Effect of HIIT Training on the Level of Adiponectin and serum concentration of Liver Enzymes in Obese boys

Sabzevari Rad, Reza; Ehsan Bakhsh, Hekmat; Fasihi Ramandi, Ebrahim

Volume 19, Issue 22 (12-2021) RSMT 2021, 19(22): 77-90 | Back to browse issues page

‎ 20.1001.1.22520708.1400.19.22.7.1

Mendeley

Zotero

RefWorks

Sabzevari Rad R, Ehsan Bakhsh H, Fasihi Ramandi E. Effect of HIIT Training on the Level of Adiponectin and serum concentration of Liver Enzymes in Obese boys. RSMT 2021; 19 (22) :77-90
URL: http://jsmt.khu.ac.ir/article-1-447-en.html

Effect of HIIT Training on the Level of Adiponectin and serum concentration of Liver Enzymes in Obese boys

Reza Sabzevari Rad

, Hekmat Ehsan Bakhsh

, Ebrahim Fasihi Ramandi

Kharazmi University , e.fasihi95@gmail.com

Abstract: (3325 Views)

Adiponectin plays an important role in many metabolic and heart diseases. Regulation of liver enzymes is also essential for the health of the body's organs. Therefore, this study aimed to evaluate the effect of a HIIT training period on adiponectin levels and serum concentrations of liver enzymes in obese and overweight boys. 22 obese and overweight boys were selected and randomly divided into two groups of control and experimental. The experimental group performed eight weeks of HIIT pedaling with 80% HR reserve intensity for 3 days a week. The variables of adiponectin, aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT) using kits and laboratory methods as well as aerobic power, body mass index, and fat percentage of tests in the two stages before and after Exercise protocol was also measured and covariance test was used to compare the research variables and Pearson correlation coefficient was used to examine the relationship. The results were analyzed at a significant level (P<0.05) using SPSS software version 24. Performing eight weeks of HIIT exercise using a bicycle resulted in a non-significant reduction in adiponectin (P>0.05), AST(P>0.05) and ALP(P >0.05) enzymes. This exercise also significantly reduced ALT enzyme (P<0.05) and fat percentage (P<0.05) and increased aerobic capacity (P<0.05)
HIIT exercise strengthens aerobic power and reduces the percentage of fat and reduces the liver enzyme ALT in obese boys. Of course, more research is needed to clarify this issue.

Keywords: Obese and Overweight Male, Adiponectin, High Intensity Interval Training, ALT, AST, ALP

Full-Text [PDF 1031 kb] (866 Downloads)

Type of Study: Research | Subject: sport physiology
Received: 2021/03/6 | Accepted: 2021/09/2 | Published: 2021/12/22

References

2. Azra T.M, Baqer L. A review of the prevalence of obesity and its management in Iran. Iranian Journal of Diabetes and Lipid Disorders. 2013;12(5):357-74.

3. Soheilipour F, Hatami M, Salehiniya H, Alaei M. Indicators of Obesity and Cardio-Metabolic Risks: Important Consideration in Adults and Children. Current Diabetes Reviews. 2022;18(1):4-11. [DOI:10.2174/1573399817666210716122123]

4. Amiri P, Ghofranipour F, Ahmadi F, Hooman H, Hosseinpanah F, Jalali-Farahani S. Personal barriers to life style modification in overweight/obese adolescents: a qualitative study. Iranian Journal of Endocrinology and Metabolism. 2009;11(5):521-601.

5. Kliegman R, Behrman R, Jenson H, Stanton B. Nelson textbook of pediatrics e-book: Elsevier Health Sciences. Philadelphia, United States. 2007.

6. Ling C, Rönn T. Epigenetics in human obesity and type 2 diabetes. Cell Metabolism. 2019;29(5):1028-44. [DOI:10.1016/j.cmet.2019.03.009]

7. Davoodi M. The effect of eight weeks selected aerobic exercise on liver parenchyma and liver enzymes (AST, ALT) of fat liver patients. Journal of Shahrekord Uuniversity of Medical Sciences. 2012;14.

8. Powell-Wiley TM, Poirier P, Burke LE, Després J-P, Gordon-Larsen P, Lavie CJ, et al. Obesity and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2021;143(21):e984-e1010. [DOI:10.1161/CIR.0000000000000973]

9. Sozen E, Ozer NK. Impact of high cholesterol and endoplasmic reticulum stress on metabolic diseases: An updated mini-review. Redox Biology. 2017;12:456-61. [DOI:10.1016/j.redox.2017.02.025]

10. Liver F. Alcoholic Liver Disease Study Group of Chinrse Liver Disease Association. Diagnostic criteria of alcoholic liver disease Zhonghua Ganzangbing Zazhi. 2003;50:72.

11. Sahin-Efe A, Katsikeris F, Mantzoros CS. Advances in adipokines. Metabolism-Clinical and Experimental. 2012;61(12):1659-65. [DOI:10.1016/j.metabol.2012.09.001]

12. Jürimäe J, Jürimäe T. Leptin responses to short term exercise in college level male rowers. British Journal of Sports Medicine. 2005;39(1):6-9. [DOI:10.1136/bjsm.2003.008516]

13. You T, Nicklas BJ. Effects of exercise on adipokines and the metabolic syndrome. Current Diabetes Reports. 2008;8(1):7-11. [DOI:10.1007/s11892-008-0003-4]

14. Lira FS, Rosa JC, dos Santos RV, Venancio DP, Carnier J, de Lima Sanches P, et al. Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor-α and negatively with adiponectin levels in obese adolescents. Metabolism. 2011;60(3):359-65. [DOI:10.1016/j.metabol.2010.02.017]

15. Kantyka J, Herman D, Roczniok R, Kuba L. Effects of aqua aerobics on body composition, body mass, lipid profile, and blood count in middle-aged sedentary women. Human Movement. 2015;16(1):9-14. [DOI:10.1515/humo-2015-0020]

16. Barani F, Afzalpour ME, Ilbiegi S, Kazemi T, Mohammadi Fard M. The effect of resistance and combined exercise on serum levels of liver enzymes and fitness indicators in women with nonalcoholic fatty liver disease. Journal of Birjand University of Medical Sciences. 2014;21(2):188-202.

17. Kawanishi N, Yano H, Mizokami T, Takahashi M, Oyanagi E, Suzuki K. Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice. Brain, behavior, and immunity. 2012;26(6):931-41. [DOI:10.1016/j.bbi.2012.04.006]

18. Slentz CA, Bateman LA, Willis LH, Shields AT, Tanner CJ, Piner LW, et al. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. American Journal of Physiology-Endocrinology and Metabolism. 2011;301(5):E1033-E9. [DOI:10.1152/ajpendo.00291.2011]

19. Kraemer RR, Castracane VD. Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin. Experimental Biology and Medicine. 2007;232(2):184-94.

20. Kamel E, McNeill G, Van Wijk M. Change in intra-abdominal adipose tissue volume during weight loss in obese men and women: correlation between magnetic resonance imaging and anthropometric measu rements. International Journal of Obesity. 2000;24(5):607-13. [DOI:10.1038/sj.ijo.0801204]

21. Kimura M, Shinozaki T, Tateishi N, Yoda E, Yamauchi H, Suzuki M, et al. Adiponectin is regulated differently by chronic exercise than by weight-matched food restriction in hyperphagic and obese OLETF rats. Life Sciences. 2006;79(22):2105-11. [DOI:10.1016/j.lfs.2006.07.003]

22. Ligibel JA, Campbell N, Partridge A, Chen WY, Salinardi T, Chen H, et al. Impact of a mixed strength and endurance exercise intervention on insulin levels in breast cancer survivors. Journal of Clinical Oncology. 2008;26(6):907-12. [DOI:10.1200/JCO.2007.12.7357]

23. Kondo T, Kobayashi I, Murakami M. Effect of exercise on circulating adipokine levels in obese young women. Endocrine Journal. 2006;53(2):189-95. [DOI:10.1507/endocrj.53.189]

24. Barkley JE, Epstein LH, Roemmich JN. Reinforcing value of interval and continuous physical activity in children. Physiology & Behavior. 2009;98(1-2):31-6. [DOI:10.1016/j.physbeh.2009.04.006]

25. Nouri Y, Rahmani nia F, Mirzaie B, Arazi H. The Effect of Resistance and Endurance Training on Resting Metabolic Rate and Body Composition in Sedentary Males. Journal of Advances in Medical and Biomedical Research. 2013;21(89):51-63.

26. Numao S, Sasai H, Nomata Y, Matsuo T, Eto M, Tsujimoto T, et al. Effects of exercise training on circulating retinol-binding protein 4 and cardiovascular disease risk factors in obese men. Obesity facts. 2012;5(6):845-55. [DOI:10.1159/000346205]

27. Paahoo A, Tadibi V, Behpoor N. The effect of 12 weeks high intensity interval training (HIIT) on testosterone, cortisol and lipid profile levels in obese and overweight boys. Metabol Exercise Bioannual Journal. 2015;15(1):85.

28. Pagano M, Gauvreau K. Principles of biostatistics: CRC Press; 2018.

29. Gibala MJ, Little JP, MacDonald MJ, Hawley JA. Physiological adaptations to low‐volume, high‐intensity interval training in health and disease. The Journal of Physiology. 2012;590(5):1077-84. [DOI:10.1113/jphysiol.2011.224725]

30. Cureton Jr T. Interpretation of the oxygen intake test. What is it? American Corrective Therapy Journal. 1973;27(1):17.

31. Hemmatinafar M, Kordi M, Choopani S, Choobineh S, Gharari Arefi R. The Effect of High Intensity Interval Training (HIIT) on Plasma Adiponectin Levels, Insulin Sensitivity and Resistance in Sedentary Young Men. Journal of Advances in Medical and Biomedical Research. 2013;21(84):1-12.

32. Kazemi A, Rahmati M, Eskandari F, Taherabadi SJ. Effect of 8 weeks sprint interval training on serum levels of Adiponectin and insulin in overweight children. Iranian South Medical Journal. 2016;19(1):37-47.

33. Souri R, Akbari M, Kazemi AR, Saei MA, Amani S. The Effect of High Intensity Training (HIT) on Serum Levels of Adiponectin and Leptin in Obese Children. Sport Biosciences. 2016;7(27):593-603.

34. Lee S, Hong H, Han T, Kang H. Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men. Biology of Sport. 2015;32(3):181. [DOI:10.5604/20831862.1150298]

35. Buchan DS, Ollis S, Young JD, Cooper S-M, Shield JP, Baker JS. High intensity interval running enhances measures of physical fitness but not metabolic measures of cardiovascular disease risk in healthy adolescents. BMC Public Health. 2013;13(1):498. [DOI:10.1186/1471-2458-13-498]

36. Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA, et al. Adiponectin is not altered with exercise training despite enhanced insulin action. American Journal of Physiology-Endocrinology And Metabolism. 2002;283(4):E861-E5. [DOI:10.1152/ajpendo.00150.2002]

37. Leggate M, Carter WG, Evans MJ, Vennard RA, Sribala-Sundaram S, Nimmo MA. Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. Journal of Applied Physiology. 2012;112(8):1353-60. [DOI:10.1152/japplphysiol.01080.2011]

38. Ryan A, Nicklas B, Berman D, Elahi D. Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women. International Journal of Obesity. 2003;27(9):1066-71. [DOI:10.1038/sj.ijo.0802387]

39. Abedi B. The Effect of 8 Weeks of High-Intensity Interval Training (HIIT) on Serum Adiponectin Levels and Insulin Resistance of Women with Type 2 Diabetes. Journal of Sport Biosciences. 2016;8(3):411-25.

40. Barani F, Afzalpour M, E, Ilbeigi S, Kazemi T, Mohamadifard M. The effect of resistance and combind exercise on serum levels of liver ensymes and fitness indicators in women with nonalcholic fatty liver diseas. Journal of Birjand University of Medical Science. 2014;21(2):188-202.

41. Barzegarzadeh-Zarandi H, Dabidy-Roshan V. Changes in some liver enzymes and blood lipid level following interval and continuous regular aerobic training in old rats. Journal of Shahrekord Uuniversity of Medical Sciences. 2012;14(5):13-23.

42. Omagari K, Kadokawa Y, Masuda J, Egawa I, Sawa T, Hazama H, et al. Fatty liver in non-alcoholic non-overweight Japanese adults: incidence and clinical characteristics. Journal of Gastroenterol Hepatol. 2002;17(10):1098-105. [DOI:10.1046/j.1440-1746.2002.02846.x]

43. Boutcher SH. High-intensity intermittent exercise and fat loss. Journal of Obesity. 2011;2011:868305. [DOI:10.1155/2011/868305]

44. Whyte LJ, Gill JM, Cathcart AJ. Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight/obese men. Metabolism. 2010;59(10):1421-8. [DOI:10.1016/j.metabol.2010.01.002]

45. Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, Haram PM, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007;115(24):3086-94. [DOI:10.1161/CIRCULATIONAHA.106.675041]