Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, the symptoms of which include a wide range of clinical symptoms, including cognitive impairment. In the present study, the effectiveness of the Rehacom rehabilitation training program based on the comprehensive model of cognitive impairment (based on the comprehensive model developed by Hazratty et al. 1403, which refers to four cognitive variables that are impaired in MS, namely: attention deficit, working memory, information processing, and fatigue, based on a systematic review) on improving cognitive impairments in people with MS was investigated. Method: This is a quantitative and applied research, and in terms of the design, it is an experimental research of the pre-test-post-test type with a control group and a follow-up after one month of the experimental group. After coordination with the Alborz MS Association, 30 people with MS were enrolled.The patients with relapsing-remitting type S were selected by convenience sampling method and randomly assigned to two experimental and control groups (15 people in each group). Then, using research tools, a pre-test (PASAT, SDMT and FSS tests) was administered to both experimental and control groups, and the Rehacom training program protocol was set up in 8 sessions. These sessions were held weekly (two sessions per week) and each session lasted 40 to 60 minutes. During the sessions, training was given through Rehacom computer cognitive tasks to improve cognitive variables. Findings: The results of the study showed that the Rehacom rehabilitation training program was effective and it seems that these training sessions were effective in improving attention deficit, working memory, information processing and fatigue.And this improvement in post-test scores and then follow-up test results in the experimental group was stable after one month. Conclusion: Given the wide range of cognitive disorders and deficiencies caused by MS, a cognitive rehabilitation training program that can include the cognitive deficiency variables of the comprehensive model and improve these cognitive variables will greatly help MS patients. The Rehacom rehabilitation program was able to improve these deficiencies well during the training sessions and its results remained stable. The results of this study can attract the attention of researchers to planning cognitive treatments
