The present study aimed to investigate the effectiveness of mindfulness-based stress reduction (MBSR) on chronic fatigue, psychosomatic symptoms, and resilience in patients with multiple sclerosis (MS) in the face of traumatic news. This study was a quasi-experimental study with a pre-test-post-test design with a control group. The statistical population included all MS patients who were members of the Hormozgan Province MS Association and who were referred to the MS ward of Omid Center, Bandar Abbas for weekly drug injections. From this population, 30 patients were selected using convenience sampling and randomly assigned to two experimental groups (n=15) and control groups (n=15). The experimental group underwent 8 sessions of mindfulness-based stress reduction intervention, while the control group did not receive any intervention. The research instruments included the Fatigue Severity Scale (FSS), the Psychosomatic Symptoms Questionnaire, and the Resilience Scale (CD-RISC). Data were analyzed using repeated measures analysis of variance. The results showed that mindfulness-based stress reduction training significantly reduced chronic fatigue and psychosomatic symptoms in patients with MS (P < 0.001). Also, this intervention was able to significantly increase the level of resilience of patients in the face of psychological stress caused by traumatic news. By strengthening the skills of being present in the moment and accepting non-judgmental, the mindfulness-based stress reduction program is considered an effective tool for managing the psychological consequences of bad news and improving the physical and mental condition of MS patients, and its use in medical centers is recommended
