The present study aimed to investigate the mediating role of emotional working memory in the relationship between attentional bias and depressive symptoms within the context of family interactions. Guided by contemporary cognitive–emotional models of depression, the study explored how negative attentional bias, as a core vulnerability factor, may influence depressive symptomatology through impairments in emotional working memory, and how these processes are embedded in the dynamics of family relationships. This research employed a descriptive-correlational design using structural equation modeling (SEM). The statistical population consisted of adults aged 20–40 years living in active family systems in Tehran in 2025. A total of 350 participants were selected through purposive convenient sampling following eligibility screening. Research instruments included measures of depressive symptoms, attentional bias, emotional working memory performance, and family interaction patterns. The results demonstrated that negative attentional bias significantly predicted higher levels of depressive symptoms both directly and indirectly. Emotional working memory showed a significant mediating role, indicating that deficits in maintaining, updating, and regulating emotional information constitute a key mechanism linking attentional bias to depressive experiences. Furthermore, family interactions functioned as an amplifying contextual factor: maladaptive and conflictual family environments strengthened the indirect pathway by increasing cognitive–emotional load and reducing regulatory resources. The final structural model showed acceptable fit indices and supported the hypothesized mediational relationships. Overall, the findings highlight the importance of integrating cognitive, emotional, and contextual variables in understanding depressive symptoms. They also underscore the potential value of interventions targeting attentional processing biases and emotional working memory capacities, particularly within family-based therapeutic frameworks.
