en Investigating the Effects of Psilocybin on Neural Tissue Repair and Neural Network Reconstruction in Comatose Patients علوم سلولی و مولکولی Cell and Molecular Biology مروری Review <div dir="ltr" style="text-align: justify;">The human body functions as an intelligent system, constantly striving to maintain its internal balance and stability while preventing disorder (entropy). The brain, as the command this system, is responsible coordinating the body&#39;s organs to maintain stability and equilibrium. However, continuous changes in environmental or physiological conditions can challenges to the brain. If the brain cannot quickly adapt to these changes, it may lead to increased entropy and, in severe cases, the collapse of the body&#39;s systems and even death. Coma is a complex condition resulting from severe brain injuries such as stroke, traumatic brain injury, infections, or oxygen deprivation. This condition not only profoundly impacts patients&#39; quality of life but It also imposes significant costs. Current treatments for coma are largely limited to life support and rehabilitation, highlighting a need for innovative therapeutic approaches. psychedelic compounds such as psilocybin have garnered attention due to their potential to promote neural repair and brain network reconstruction. Psilocybin, an active compound found in &quot;magic mushrooms,&quot; works by activating serotonin receptors (particularly HT2A) and upregulating neurotrophic factors such as BDNF. These mechanisms enable psilocybin to reduce neural inflammation and enhance neurogenesis and synaptogenesis. Psilocybin offer new hope for the development of effective treatments.</div> <div style="text-align: justify;">The human body functions as an intelligent system, constantly striving to maintain its internal balance and stability while preventing disorder (entropy). The brain, as the command this system, is responsible coordinating the body&#39;s organs to maintain stability and equilibrium. However, continuous changes in environmental or physiological conditions can challenges to the brain. If the brain cannot quickly adapt to these changes, it may lead to increased entropy and, in severe cases, the collapse of the body&#39;s systems and even death. Coma is a complex condition resulting from severe brain injuries such as stroke, traumatic brain injury, infections, or oxygen deprivation. This condition not only profoundly impacts patients&#39; quality of life but It also imposes significant costs. Current treatments for coma are largely limited to life support and rehabilitation, highlighting a need for innovative therapeutic approaches. psychedelic compounds such as psilocybin have garnered attention due to their potential to promote neural repair and brain network reconstruction. Psilocybin, an active compound found in &quot;magic mushrooms,&quot; works by activating serotonin receptors (particularly HT2A) and upregulating neurotrophic factors such as BDNF. These mechanisms enable psilocybin to reduce neural inflammation and enhance neurogenesis and synaptogenesis. Psilocybin offer new hope for the development of effective treatments.</div> 5-HT2A Receptor, Coma, Neurogenesis, Psilocybin, Synaptogenesis 5-HT2A Receptor, Coma, Neurogenesis, Psilocybin, Synaptogenesis 0 0 http://nbr.khu.ac.ir/browse.php?a_code=A-10-1679-1&slc_lang=en&sid=1 SeiedAbdolhmid Angaji SeiedAbdolhmid Angaji Angaji@khu.ac.ir 100319475328460011629 100319475328460011629 Yes Zahra Shahidi sadeghi Zahra Shahidi sadeghi Shahidizahra5@gmail.com 100319475328460011630 100319475328460011630 No Department of Cellular and molecular biology, Faculty of Biological Sciences,Kharazmi University ,Tehran, Iran