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Volume 12, Issue 8 (10-2014)
Abstract
Background: This study aimed to examine the effects of endurance swimming training during pregnancy on pregnant rat’s neonate liver tissue apoptotic index. Methods: 16 pregnant rats (200 ± 20 g) were divided into two swimming and control groups. The rats of training group were forced from first day of pregnancy to delivery in a particular pool. The sampling of the neonate liver tissue was performed two days after born and the liver apoptotic percent index was determined with TUNEL technique. Statistical analysis of the data was done using independent t-test (ɑ ≤0.05). Results: The results showed that the average neonate liver apoptotic index in the control and training group respectively was 6.40% and 6.20% that indicate no significant difference between two groups (p<0.05). In addition, exercise produced no significant changes in birth weight (p <0.05). Conclusion: These results suggest that swimming endurance training during pregnancy maybe have no negative and worrying impact on neonate growth and liver apoptotic index.
Mohammad Azimnezhad, Pezhman Motamedi, Mohammadreza Dehkhoda, Neda Khaledi,
Volume 20, Issue 23 (9-2022)
Abstract
Apoptosis is a programmed cell death and it’s associated with type 2 diabetes. The aim of present study was to investigate the effect of endurance training on caspase-3, Bcl-2 and Bax gene expression of cardiac tissue in type 2 diabetic male wistar rats.In an experimental trial, 36 male wistar rats were randomly divided into three groups, Diabetic Endurance Training (n=12), Diabetic Control (n=12) and Healthy Control (n=12). Type 2 diabetes was induced by intraperitoneal injection of STZ. The endurance training included 10 weeks, 5 sessions per week running at speed of 27 m/min for 20-30min in 1st week and reached to 27 m/min for 60 min/day in 10th weeks. The animals were sacrificed 24 h after last training session and the samples were taken from cardiac tissue. The gene expression of caspase-3, Bcl-2 and Bax were examined by Real time-PCR. The one-way ANOVA was used to analysis the data. The significant level was set at p<0.05. The gene expression of caspase-3and Bax of diabetic control group showed significant increase comparing with healthy control group (p =0.001) while gene expression of Bcl-2 significantly decreased (p =0.001). The endurance training induced significant reduction in the gene expression of caspase-3and Bax (p =0.001) and significant increase in the Bcl-2 compared to diabetic control group (p =0.001). It appears that gene expression of caspase-3, Bcl-2 and Bax of diabetic cardiac tissue are affected by positive effect of endurance training and the endurance training induces improvement in apoptosis of diabetic cardiac tissue.
