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The Effect Of Eight Weeks Of Endurance Training On The Expression Of Glutathione Peroxidase 4 And Malondialdehyde In The Soleus Muscle Of Aged Aale Wistar Rats
Mojtaba Salehpour, Ali Sarlak, Hadi Samadi,
Volume 21, Issue 26 (12-2023)
Abstract
Introduction: The increase of iron due to aging affects the process of ferroptosis, and the final product of lipid peroxidation, MDA, is the central regulator of ferroptosis. Therefore, the aim of the research was to determine the effect of eight weeks of endurance training on the expression of GPX4 and MDA in the soleus muscle of aged male rats.
Materials and Methods: This study is of an experimental type. 20 healthy rats were divided into two groups of 10 each: training group and control group. The training was done incrementally for eight weeks. 48 hours after the last training session, the soleus muscle of mice was surgically removed and the amount of variables was measured by gene expression and ELISA methods.
Results: There was no significant difference in the level of GPX4 gene expression in the soleus muscle of exercise group rats compared to control group rats (p=0.4079). But the amount of MDA in the training group was significantly reduced compared to the control group (p=0.0028).
Conclusion: According to the findings of the present research, it seems that the effect of endurance training in this research shows a decrease in ferroptosis. The absence of a significant difference in the level of GPX4 gene expression is a sign that endurance training with this intensity does not affect it.
The Effect Of Six Weeks Of TRX Training On Serum GDNF Protein Level Of Elderly Women
Mojtaba Salehpour, Faezeh Rezvani, Farzane Hatami,
Volume 23, Issue 30 (1-2026)
Abstract
Background: GDNF protein that is effective in neurocognitive plasticity and sarcopenia, increases with resistance training. The aim of the research is the effect of six weeks of TRX training on the GDNF protein level in the serum of elderly women.
Materials and methods: The purpose of the research is applied with a semi-experimental method including pre-test-post-test with control group.28 elderly women from retirement center of Teacher Training University,Shahid Rajaei, were randomly assigned to the experimental group (n=15) with an average age of 60.86±5.60,BMI 27.65±4.22 ,control group (n=13) with an average age of 64.38±4.03,BMI 28.33 ± 2.18. In the first and last weeks, upper and lower body strength tests and GDNF protein levels were measured by ELISA kit .Shapiro-Wilk test for normality of data distribution,Levin test for homogeneity of variances,one-way analysis of covariance test (P<0.05) were performed to test hypotheses with spss24 software.
Results: Covariance analysis of upper and lower body strength were significantly different between groups (P<0.05).In adjusted averages,the GDNF protein level in the experimental group (443.102±15.751) is significantly higher than the control group (209.756±17.029)(P<0.05).
Conclusion: Six weeks of TRX training had a significant effect on the amount of GDNF protein, upper and lower body strength of elderly women, and can probably be effective in reducing or delaying sarcopenia.

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