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Elham Shahabpoor, Mohammad Amin Delavari,
Volume 21, Issue 26 (12-2023)
Abstract

Cachexia syndrome and the risk of cardiovascular diseases are highly prevalent in cancer patients.The purpose of the present study was to investigate the effect of endurance training as a therapeutic method on muscle cachexia and cardiovascular consequences caused by breast cancer.  After 2 weeks of breast cancer induction, 20 BALB/c mice (age: 6-8 weeks and weight: 17- 18 g) mice performed the maximum aerobic capacity test and were randomly allocated into tumor-control and tumor-exercise groups. The tumor-exercise group performed the endurance Training protocol for 6 weeks, 5 days a week with gradual increase in intensity from 12 to 20 (m.min-1) and duration from 25 to 55 minutes And 24 hours after the last training session, the maximum aerobic capacity test was performed. 48 hours after the last training session, the mice were sacrificed. Heart weight, weight of gastrocnemius and soleus muscle, heart mass index, ratio of weight of soleus muscle to body weight and ratio of weight of gastrocnemius muscle to body weight were measured in tumor-control and tumor-exercise groups. Data were analyzed by independent t-test at the significance level of P≥0.05. The results of the present study showed a significant increase in heart weight (P=0.005), spleen weight (P=0.029), weight of the gastrocnemius muscle (P=0.009) and soleus muscle (P=0.022) in the tumor-exercise group compared to the tumor-control group. Also, significant increase in the heart mass index (P=0.016) and the ratio of the weight of the gastrocnemius muscle to the body weight (P=0.005) and the ratio of the soleus muscle to the body weight (P=0.021) were observed in the tumor-exercise group compared to the tumor-control group. In conclusion,Endurance training seems to be a potential treatment method and strategy to improve the health of the skeletal muscle and cardiovascular system and reduce the process of muscle cachexia caused by breast cancer.




Mohsen Mohammadnia Ahmadi, Razieh Heidari,
Volume 21, Issue 26 (12-2023)
Abstract

Nowadays, the use of traditional herbal remedies for the prevention and treatment of diseases along with exercise has become very popular. The aim of this study was to investigate acute effect of hydro alcoholic extract of melissa officinalis on metabolic rate, substrate oxidation and salivary cortisol during and after high-intensity interval exercise (HIIE) in inactive women. Ten inactive women were selected based on criteria (BMI 22.28±0.60 kg/m2). Individuals participated in two separate sessions. In the first session, extract of melissa officinalis (500 mg) were intake one hour before HIIE. In the second session, the placebo (500 mg of starch) was intake. The HIIE program consisted of 11 alternates (1-minute with 90% vVO2max followed by 2-minute rest intervals with 60% vVO2max). Pre, during and after HIIE, respiratory gases was measured using the respiratory gas analyzer and was used to calculate metabolic rate (Energy Expenditure, VO2) and substrate oxidation (Fat oxidation, Respiratory Exchange Ratio (RER)). Heart rate monitored by polar sensor. Salivary cortisol after collection was measured by chemiluminescence method. Based on results, there was no significant difference in VO2 (P =0.51), Fat Oxidation (P= 0.9), RER (P= 0.76), Heart rate (P= 0.42) and energy expenditure (P=0.6) between melissa officinalis and placebo intake. Also, there was no significant difference in salivary cortisol (P= 0.15). Generally, hydro alcoholic extract of melissa officinalis supplement intake along HIIE has no effect on metabolic rate, substrate oxidation and cortisol level in inactive women.

 
Hamdollah Hadi,
Volume 21, Issue 26 (12-2023)
Abstract

The purpose of this research was to determine the effect of different doses of caffeine chewing gum on stress hormones and shooting performance of military men. The subjects of the present research were 10 commanders of Valiasr Police Training Center in Tabriz with a mean and standard deviation of age of 31.52±2.78 years, weight of 75.32±3.91 kilograms, His height was 176.14 ± 4.84 cm. The levels of cortisol, adrenocorticotropic hormone and oxytocin in the blood as well as shooting performance were measured after consuming different doses of caffeine. In the first phase, the placebo was given 15 minutes before the shooting. In the second, third and fourth stages (the time interval between each stage is 5 days), all the subjects were given caffeine gum with doses of 150, 200 and 300 mg 15 minutes before the shooting. Gum and placebo were given to the participants in a double-blind manner. Descriptive statistics, analysis of variance with repeated measures and Tukey's post hoc test were used to analyze the data(P≤0.05). The results of the present study showed that the consumption of caffeine gum in doses of 200 and 300 grams causes a significant decrease in all three stress hormones and also a significant increase in shooting performance, however, the consumption of a dose of 150 mg of caffeine don’t have an effect on the reduction of stress hormones and Shooting performance. According to these results, shooting athletes can be advised to use caffeine gum with doses of 200 and 300 mg before their training and competitions. However, more studies are needed to comment on the use of different doses of caffeine, especially in the form of chewing gum.

 

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