Dr Ali Asghar Ravasi, Dr Mousa Khalafi, Dr Karim Azali Alamdari,
Volume 19, Issue 22 (12-2021)
Abstract
Background and objective: Effects of exercise training on metabolic disorders through modifications in fibroblast growth factor -21 (FGF-21) level are controversial. Therefore, the aim of study was to determine the quantitative effect of exercise training protocols on serum FGF-21 level in adults with metabolic disorders. Methods: A systematic search of the published Persian or English-language studies from PubMed and Google Scholar databases up to march 2021 was done and standardized mean differences (SMDs) were calculated using random-effects models. Results: a total of 14 studies (aerobic training=3, resistance training=3, HIIT=4, concurrent training=4) including on 19 interventions conducted on 503 subjects (with overweight, obesity, type 2 diabetes, metabolic syndrome and or fatty liver disease) were eligible to include in the meta-analysis. However, because of the heterogeneity, the final quantitative impact of 16 interventions was calculated as a declining serum FGF21 level after training [SMD=-0.44(CI: -0.65 to -0.22) p=0.001] which had no correlation with subjects age(p=0.10) or BMI(p=0.50) level. Conclusion: exercise training protocols are efficient tools for a remarkable decrease in serum FGF-21 in patients with metabolic disorders which seems to lead to more beneficial effects on metabolic disturbances. However, more clinical trials are still warranted in this area considering the role of exercise components such as exercise intensity and type
Reza Sabzevari Rad, Hekmat Ehsan Bakhsh, Ebrahim Fasihi Ramandi,
Volume 19, Issue 22 (12-2021)
Abstract
Adiponectin plays an important role in many metabolic and heart diseases. Regulation of liver enzymes is also essential for the health of the body's organs. Therefore, this study aimed to evaluate the effect of a HIIT training period on adiponectin levels and serum concentrations of liver enzymes in obese and overweight boys. 22 obese and overweight boys were selected and randomly divided into two groups of control and experimental. The experimental group performed eight weeks of HIIT pedaling with 80% HR reserve intensity for 3 days a week. The variables of adiponectin, aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT) using kits and laboratory methods as well as aerobic power, body mass index, and fat percentage of tests in the two stages before and after Exercise protocol was also measured and covariance test was used to compare the research variables and Pearson correlation coefficient was used to examine the relationship. The results were analyzed at a significant level (P<0.05) using SPSS software version 24. Performing eight weeks of HIIT exercise using a bicycle resulted in a non-significant reduction in adiponectin (P>0.05), AST(P>0.05) and ALP(P >0.05) enzymes. This exercise also significantly reduced ALT enzyme (P<0.05) and fat percentage (P<0.05) and increased aerobic capacity (P<0.05)
HIIT exercise strengthens aerobic power and reduces the percentage of fat and reduces the liver enzyme ALT in obese boys. Of course, more research is needed to clarify this issue.
Mohammad Azimnezhad, Pezhman Motamedi, Mohammadreza Dehkhoda, Neda Khaledi,
Volume 20, Issue 23 (9-2022)
Abstract
Apoptosis is a programmed cell death and it’s associated with type 2 diabetes. The aim of present study was to investigate the effect of endurance training on caspase-3, Bcl-2 and Bax gene expression of cardiac tissue in type 2 diabetic male wistar rats.In an experimental trial, 36 male wistar rats were randomly divided into three groups, Diabetic Endurance Training (n=12), Diabetic Control (n=12) and Healthy Control (n=12). Type 2 diabetes was induced by intraperitoneal injection of STZ. The endurance training included 10 weeks, 5 sessions per week running at speed of 27 m/min for 20-30min in 1st week and reached to 27 m/min for 60 min/day in 10th weeks. The animals were sacrificed 24 h after last training session and the samples were taken from cardiac tissue. The gene expression of caspase-3, Bcl-2 and Bax were examined by Real time-PCR. The one-way ANOVA was used to analysis the data. The significant level was set at p<0.05. The gene expression of caspase-3and Bax of diabetic control group showed significant increase comparing with healthy control group (p =0.001) while gene expression of Bcl-2 significantly decreased (p =0.001). The endurance training induced significant reduction in the gene expression of caspase-3and Bax (p =0.001) and significant increase in the Bcl-2 compared to diabetic control group (p =0.001). It appears that gene expression of caspase-3, Bcl-2 and Bax of diabetic cardiac tissue are affected by positive effect of endurance training and the endurance training induces improvement in apoptosis of diabetic cardiac tissue.
Saeed Vahedi, Mareft Siah Koohian, Milad Rahati, Negar Rostami, Elaheh Fallahzadeh, Roghayeh Afrondeh,
Volume 20, Issue 23 (9-2022)
Abstract
Covid 19 disease is associated with a wide range of clinical symptoms and long-term complications. For most sports medicine professionals, it's a new challenge for people to resume their previous activities after recovering from Covid 19 after receiving the exercise prescription and care. The aim of this study was to review the appropriate physical activity for those recovering from Covid 19 infection based on the type of involvement they developed during the illness. For this study, a review study method was selected. This is done in three steps. In the first stage, physical activity in Quid, in the second stage, organ involvement in Quid, and in the third stage, sports prescriptions in organ involvement by searching for appropriate keywords in reputable scientific databases such as Pubmed, ACSM, SID. ir and Science Direct were searched, content related to the purpose of the articles were extracted and collected and analyzed for content. Examination of organs after recovery from Covid 19 infection is essential to return to physical activity. Physical activity prescriptions in those recovering from Corona varies from disease to patient, and organ to organ. Exercising in Covid conditions requires consideration. The cardiovascular, respiratory, blood, gastrointestinal, and musculoskeletal systems are affected by Covid 19 infection. Exercise, on the other hand, has different effects on the immune system depending on its severity, and the immune system undergoes changes in Covid 19 disease. The type, intensity, and duration of exercise or physical activity vary according to the patient and the symptoms or side effects left by Quid, and the readiness of the various organs for physical activity should be assessed.
Dr Adel Donyaei, Mustafa Rahimi, Fatemehsadat Nabavi,
Volume 20, Issue 24 (3-2023)
Abstract
vitamin D deficiency is associated with many cardiovascular disorders. Arterial stiffness responses also depend on nutritional and exercise. Therefore, the study aimed to investigate the relationship between arterial stiffness response after glucose uptake and exercise with baseline levels of vitamin D in inactive men and women.
The present study was an analysis correlation study, and the subjects were 88 inactive men and women with an age range of 20 to 45 years. Vitamin D, body composition, and arterial stiffness, were measured. Subjects then ran for 30 minutes at 65% of maximum heart rate. Also, 75g of glucose was given to the subjects after 30 minutes of activity, 60 minutes after the of glucose consumption and arterial stiffness was measured. Data were analyzed using Pearson correlation test and analysis of variance with repeated measures at a significant level (P≤0.05).there was a negative and significant relationship between baseline levels of vitamin D and changes in CAVI in women (p=0.001 and r=-0.559) and in men a positive and significant relationship (p=0.005 and r=0.413).It seems that basal levels of vitamin D can be effective in the vascular response; due to little research, more research is need.
Dr Majid Kashef, Dr Maral Ramez, Azam Ahmadi,
Volume 20, Issue 24 (3-2023)
Abstract
It is estimated that by 2035, more than 130 million adults will suffer from various types of cardiovascular diseases. Therefore, it is very important to know the pathogens of cardiac diseases and investigate new treatments. Also, despite continuous progress in diagnosis, patient education, and risk factor management, myocardial infarction (MI) remains one of the most common causes of morbidity, hospitalization, and mortality worldwide. The events associated with MI are highly complex and characterized by rapid metabolic and biochemical changes. Exercise training is an effective cardioprotective strategy that reduces adverse effects of MI and ischemia/reperfusion (I/R). Multiple signaling pathways of exercise preconditioning in mitigating MI-induced cardiac damage is one of the topics that has attracted much attention. In this article, some of the contributing factors in exercise-induced cardiac protection, including mitochondrial changes, metabolic changes, vascular adaptations, antioxidant capacity, heat shock proteins, cyclooxygenase levels, ATP-sensitive potassium channels, adenosine, protein kinase C, calcium and klotho homeostasis are discussed.
Dr Ali Barzegari, Dr Saeid Naghibi, Samaneh Safayi, Dr Mohammadhasan Dashti Khovidaki, Dr Anahita Salehi,
Volume 20, Issue 24 (3-2023)
Abstract
The purpose of this study was to compare two methods of aerobic exercise on the levels of SOD and TNF-α in the heart tissue of diabetic rats. 40 male Wistar rats aged ten weeks were randomly divided into four groups of 10: healthy control, diabetes, diabetes+MIT and diabetes+HIT. The moderate intensity training group ran 5 sessions per week for 8 weeks on the treadmill for 60 minutes at a speed of 25 meters per minute, and the high intensity training group also 5 sessions per week for 8 weeks with a training time of 60 minutes and at a speed of 34 meters per minute. The heart tissue of rats was examined to determine the amount of changes in SOD and TNF-α using ELISA method. To investigate the difference between groups of variables, one-way analysis of variance and Tukey's post hoc statistical tests were used at the significance level of P≥0.05. The results showed that there was a significant difference in the levels of TNF-α and SOD in the heart tissue of rats among the four research groups (P≤0.001). The levels of TNF-α in the HIT training group also showed a significant decrease compared to the diabetic group (P=0.001), While these changes in the MIT exercise group compared to the diabetes group was a non-significant decrease (P=0.117), the amount of SOD levels between the MIT and HIT exercise groups also showed a significant increase compared to the diabetic group (P=0.001). It seems, aerobic exercise with different intensities can improve SOD and TNF-α levels. Although the intensity of exercise in periodic exercise has been an effective factor in changing the values of both variables.
Mr Behzad Mohamadi Orangi, Dr Rasoul Yaali, Dr Mohammad Taqi Aghdasi,
Volume 20, Issue 24 (3-2023)
Abstract
The aim of this study was to Compare Effectiveness motor proficiency of the nutritional status on men in different age groups ((children, adolescents and young adults)), respectively. Statistical Society study was for children all student ages 10-7 years, for adolescents all student ages 15-12 years and for Youth of all students 20-18 of Tehran University except the student physical education. The sample was 90 people in each of the age groups, the four elementary schools and four high schools in Tehran and Tehran University male students were chosen by cluster sampling. This study was a descriptive survey and comparison measurement was test of instruments anthropometric and Brvnynks- Oseretsky. The results showed that among malnutrition, moderate nutrition and proper nutrition in adolescence and adulthood motor proficiency was not statistically different ages but among children ages motor proficiency were significantly different. In addition, no significant difference between motor proficiency age groups. It seems due to the impact of nutritional status on motor proficiency, and this issue was observed in this study at an early age; therefore, children are the most vulnerable in this context and considering the nutritional status of children is very important.
Dr Rasul Eslami, Navab Abnama,
Volume 20, Issue 24 (3-2023)
Abstract
The aim of the present study was to investigate The effect of HMB-FA supplementation on the muscle damage markers after soccer matches. 24 male soccer players (age: 23±3 years, BMI: 22.8±2 kg/m2) were voluntarily selected as the statistical sample of this study and were divided into two Suppplement and Placebo groups (n=12). In this study, subjects participated in a weekly soccer microcycle with two matches. Subjects in the supplement-training group consumed three grams of HMB-FA daily during a weekly soccer cycle. Blood samples were taken in seven times (before supplementation, before the first match, immediately after the first match, 24 hours after the first match, before the second match, immediately after the second match, 24 hours after the second match). Plasma concentrations of creatine kinase (CK) and lactate dehydrogenase (LDH) were measured by ELISA kits. Data analysis was performed using Friedman, Wilcoxon, Kruskal-Wallis and U Mann-Whitney tests with a significance level of p ≥ 0.05. After supplementation, a significant decrease in plasma levels of lactate dehydrogenase (before and after the first match) and creatine kinase (in the times immediately after the first match and before the second match) was observed (for all, p <0.05). Intaking HMB-FA supplement reduced the markers of muscle damage, which is essential for recovery from injuries caused by training and competition during a two race cycle. In addition, inaking HMB-FA supplement may have other effects, including reducing neuromuscular fatigue, reducing the inflammatory response, and rapid skeletal muscle regeneration, which requires further study.
Mr Reza Asadi, Dr Mohammad Reza Kordi, Dr Fatemeh Shabkhiz,
Volume 21, Issue 25 (9-2023)
Abstract
Neurodegenerative processes play an important role in the progression of MS. Appropriate exercise training and living in an enriched environment (EE) can improve or prevent the progression of the disease through the secretion of some neurodevelopmental factors in the hippocampus, including irisin and the neutrophic factor derived from the mouse. The aim of the present study was to investigate the effect of 4 weeks of aerobic and resistance training and EE on irisin protein and hippocampus BDNF levels in female C57BL6 mice with experimental autoimmune encephalomyelitis (EAE). 50 female mice (age 8 weeks, average weight 18 ± 2 grams) were randomly divided into five equal groups (10 mice in each group): 1- healthy control, 2- control + EAE, 3- resistance activity + EAE, 4- Aerobic activity + EAE and 5- EE + EAE. The first and second weeks of adaptation to the environment and then induction of EAE were performed. The training groups trained 5 days a week for half an hour a day for 4 weeks, and the EE group was transferred to its equipped cage. 48 hours after the last training session, the mice were anesthetized and then dissected and tissue removed. The ELISA method was used to measure the amounts of proteins, and the analysis of variance and Tukey's t-test were used to determine the differences between the research variables. All analyzes were performed at a significance level of 0.05 and with SPSS22 software. Hippocampal BDNF expression was increased in all three training groups compared to the EAE control group. This increase in the EE and resistance training group was significant compared to both the EAE control group and the swimming training group. Also, hippocampal irisin expression increased in all three training groups compared to the EAE control group, and this increase was significant in the EE and resistance training groups. Also, the expression of irisin in the EE group increased more than the two aerobic swimming and resistance training groups, and this increase was proportional to It was meaningful to the swimming aerobic training group. It seems that EE and resistance training can increase the secretion of nerve growth factors such as irisin and BDNF and thus help to improve MS disease.
Mr Kourosh Dehghan, Dr Khosro Jalali Dehkodi, Dr Farzaneh Taghian, Dr Mehdi Kargarfard, Dr Bahram Abedi,
Volume 21, Issue 25 (9-2023)
Abstract
Osteoporosis is the most common metabolic bone disease, and various factors such as low body mass index and lack of physical activity are involved in the occurrence of this disease. The aim of this study was to evaluate the effect of circular resistance exercises, whole body vibration and their combination on 25-hydroxyvitamin D, bone mineral density and functional factors in elderly people with osteoporosis. In a randomized controlled experiment with a pre-test-post-test design, 60 elderly men with osteoporosis with an age range of 65-78 years were randomly divided into four exercise groups: Circular resistance training (CRT, n=15), whole body vibration training (WBVT, n=15), combined (CRT + WBVT, n=15), and control (n=15). CRT with an intensity of 30 to 60% of the maximum repetition strength (1RM) was performed 3 times a week for 12 weeks. WBVT were performed in the form of 10 combined lower body and upper body movements with a frequency intensity between 25 to 45 Hz, an amplitude of 5 to 8 mm, and a time of each movement of 60 to 100 seconds, While the control group maintained their usual lifestyle. Body composition variables include; Fat-free weight (LBM), soft tissue weight (SLM) and skeletal muscle weight (SMM) using Body Composition Analyzer, bone density measurement using DEXA test and 25-hydroxyvitamin D3 before and after the last training sessions. Data analysis was done by using paired sample t-test and analyze of covariance (ANCOVA) at a level less than 0.05. After 12 weeks of intervention, a significant improvement in BMD, balance, coordination, muscle strength, lean weight and skeletal muscle weight was observed after CRT and CRT + WBVT exercises in comparison with the control group. However, no significant differences were observed between the groups in the variables of weight, body mass index, lean weight, soft tissue weight, skeletal muscle weight (SMM), BMD, balance, hydroxyvitamin D3 (p> 0.05). The findings of the current research show that performing CRT, WBVT and CRT + WBV exercises as a non-pharmacological treatment method can cause a significant increase in bone density and functional indicators of elderly men and has no effect on the hormonal indicators of elderly men with osteoporosis. Further studies with long-term follow-up should be considered to confirm these findings.
Dr Seyed Kazem Mousavisadati, Ms Sima Nazari, Dr Keyvan Molanorouzi,
Volume 21, Issue 25 (9-2023)
Abstract
The purpose of this research was to investigate the effectiveness of snorkeling on teaching basic swimming skills in non-swimmer children and teenagers with fear of water. This research was an experimental type with a pre-test and post-test design with a control group. The participants were 30 children (8.95±0.64 years old) and 30 teenagers (15.06±0.71 years old) non-swimmers who were afraid of water, and the participants of each group were randomly divided into two experimental and control groups (15 people in each group). After participating in the pre-test of skills of entering the water, opening the eyes in the water, gliding, orientation in the water and movement in the water and breath holding, all four groups entered a 20-session course of swimming training, so that the experimental group with snorkel and the control group without snorkel were taught basic swimming skills by an instructor. Then all four groups participated in the post-test. The data were analyzed by two-factor multivariate analysis of covariance (MANCOVA) and Benferoni's post hoc test. The results of the findings show that the main effects of age were not significant, but the main effects of training and the interactive effects of age and training were significant. Using a snorkel in children and teenagers did not have a significant effect on the skill of entering the water, opening the eyes in the water, but it had a significant and positive effect on the skills of gliding, orientation in the water and movement in the water. Also, the use of snorkel in children and teenagers had a significant and negative effect on breath holding skill. Considering that the results of the present study show the positive effects of using a snorkel on learning the skills of gliding and orientation in water and moving in water and its negative effect on breath holding skill in children and teenagers, it is recommended that the instructors who use snorkel to acclimatize children and teenagers to the water, provide additional training to improve the skill of holding their breath.
Mrs Sedigheh Nosrati Abarghoee, Mrs Fatemeh Nematian, Dr Roohangiz Norouzinia, Mrs Fatemeh Edalat, Mrs Dorrin Nikbakht,
Volume 21, Issue 25 (9-2023)
Abstract
Nurses, especially nurses in the intensive care unit, experience significant job stress that can endanger their health and cause a decrease in their sleep quality and happiness, and as a result, the quality of care for patients, and considering that the working conditions of the nurses in the intensive care unit Especially, it is in a way that increases emotional pressure and sad mood. Therefore, this study was conducted with the aim of determining the effect of online Pilates exercise on the quality of sleep and happiness of nurses in the intensive care unit.
The study was a quasi-experimental type of pre-test-post-test with two intervention and control groups and was conducted on 70 female nurses with an average age of 30.14±3.26. The intervention was held online in 8 sessions (3 sessions per week, 50 minutes in the afternoon in the form of warm-up exercises, main exercises and cooling down). Data were collected using the Pittsburgh Sleep Quality and Oxford Happiness Questionnaires and analyzed with spss 23 software and chi-square, t-test, and Mann-Whitney tests. At the beginning of the study, there was no statistically significant difference between the two groups. But at the end of the intervention, the average score of total sleep quality (p=0.045) and happiness (p=0.0001) showed a significant improvement in the intervention group.To improve physical and mental health, improve the quality of life, sleep and happiness, classical Pilates exercise can be recommended to be included in daily programs.
Mrs Nasim Sivandi, Dr Rohollah Nikooie, Dr Darioush Moflehi,
Volume 21, Issue 25 (9-2023)
Abstract
Amino acid taurine can increase the utilization of fatty acids and stimulation of lipolysis through augmentation of the expression of genes related to regulation of energy metabolism. The purpose of this study was to investigate the effect of taurine supplement on lipid oxidation and substrate selection during exercise in obese women. 15 obese women (Body weight: 34.53 ± 6.33 (kg), BMI: 33.12 ± 3.23 (kg/m2)) performed a standard incremental test before and after 21 days of taurine supplementation (50 mg/kg). Blood samples were collected before and after the test and breath by breath mesurment of respiratory parameters were done throughout the test. FATmax (as the point at which fat contributes the most to the consumed energy) and Cross over point (as the point at which the predominant fuel changes from fat to carbohydrates, COP) were calculated. Heart rate, workload, and oxygen consumption corresponding to FATmax and COP were determined and compared between attempts before and after supplement consumption using independent t-test and analysis of variance with repeated measures. Following taurine consumption for 21 days, the changes in serum levels of estrogen and progesterone hormones, maximum oxygen consumption, and time to exhustion during incremental exercise test were significantly higher than before supplement consumption. Nevertjeless, the consumption of supplement had no effect on heart rate, workload and oxygen consumption corresponding to FATmax and COP points. Despite the increase in performance variables during exercise, taurine supplementation has no effect on substrate selection during exercise in obese women.
Dr Malihe Aveseh, Dr Maryam Koushkie Jahromi, Dr Javad Nemati, Dr Saeed Esmaeili Mahani,
Volume 21, Issue 25 (9-2023)
Abstract
Lactate has been recently considered as a signaling factor involved in metabolism. The aim of this study was to investigate the role of lactate entrance into the brain on endurance training-induced adaptations in lipid oxidation.
24 male rats (age: 8 weeks, weight: 197 ± 21 g) were divided into control (C), trained (T), and traind+4-CIN (T+4-CIN, which experienced the inhibition of lactate entrance into the brain during exercise). All animals performed a single session of acute endurance exercise following their 12-weeks training protocol. Free fatty acids (FFA) and triglyceride content in plasma and adipose tissue and cAMP and Inositol triphosphate (PI3) content in epididymal fat were measured immediately after acute exercise using ELISA and were compared among the groups by one-way analysis of variance (ANOVA).
Acute exercise significantly increased lactate concentration in cerebrospinal fluid (SCF) in both T and T+4-CIN compared to the C group. Lactate concentration was slightly lower in T + 4-CIN compared to the T. Immediately after acute endurance training, a significant decrease of 61 and 31% in plasma triglyceride levels, a significant decrease of 39 and 26% in adipose tissue triglyceride levels, a significant increase of 125 and 56% in plasma FFA levels, a significant increase of 217 and 125% increase in FFA plasma levels, a significant increase of 87 and 41% in adipose tissue cAMP levels, and a significant increase of 90 and 49% in adipose tissue inositol triphosphate levels was observed in the T and T+4-CIN compared to the control group, respectively (all P < 0.01). Plasma triglyceride and adipose tissue levels in the 4-CIN + training group were significantly higher and plasma and adipose tissue FFA levels were significantly lower (all P < 0.05) than the values found in the T group. In conclusion, the results of the present study showed that lactate can be effective on endurance training-induced adaptations in lipid oxidation due to its action in the brain.
Dr Mostafa Haj Lotfalian, Dr Heydar Sadeghi, Mr Soroosh Bagheri,
Volume 21, Issue 25 (9-2023)
Abstract
The purpose of this study was to examine and compare the difference between inside kick, outside kick, toe foot kick and cheap kick with maximum effort, in some parameters associated with the electromyographic activity of the quadriceps muscle. Eight skilled collegiate soccer players volunteered as subjects in the study. These variables were included the average and maximum activation, activation time (AT), the time which the muscles reached to zenith activity (ZAT) and work (W). In order to calculate electromyography of selected muscles contain, RectusFemuris, VastusMedialis and VastusLateralis, ME6000 apparatus with 1080 Hz sample rate was used. Paired sample t-test was used to analyze data. The results indicate similarity between outside and toe foot kicks in average and maximum activity, activation time and work. thus there was no significant difference in electromyographic activity of the quadriceps muscles between these two kicks. But in many parameters, these two kicks were different with inside and cheap kicks. In a nutshell, according to the results, it can be said, quadriceps muscles during various kicks, adapting different trend of contraction which are dependent on the position of the muscles and limbs interaction during soccer kick. And outside kick could be created maximum stimulation in quadriceps.
Mohsen Soltani, Ali Barzegari, Saeed Naghibi, Mohammad Hassaan Dashty Khavidaki,
Volume 21, Issue 26 (12-2023)
Abstract
This study aimed to investigate the effect of quercetin supplementation and training on myostatin and follistatin levels in the heart tissue of diabetic rats. Methods: For this purpose, 50 10-week-old male Wistar rats with an average weight of 237±33 grams were randomly divided into five groups of 10 including: healthy control, diabetes, diabetes+supplement, diabetes+exercise, and diabetes+supplement+exercise. . The training protocol includes five sessions per week for eight weeks on a treadmill without a special slope. The rodents ran for 60 minutes at a speed of 25 meters per minute in each session.and the supplement groups received 50 mg/kg quercetin daily by gavage. The results showed that the difference in myostatin levels among the groups is significant (P=0.001). There was a significant decrease in myostatin levels between exercise+supplement+diabetes group with diabetes (P=0.002). There was also a significant difference between the supplement+diabetes and exercise+diabetes groups (P=0.009). Also, the results showed that the difference in follistatin levels among the groups is significant (P=0.001). The results showed that follistatin levels in the heart tissue increased significantly between the groups of diabetes, exercise+diabetes, supplement+diabetes and exercise+supplements+diabetes with the control group (respectively: P=0.005; P=0.001; P=0.001; P = 0.001).
It seems that moderate intensity aerobic exercise and quercetin supplementation have a positive and beneficial effect on the levels of myostatin and folstatin.
Mojtaba Salehpour, Ali Sarlak, Hadi Samadi,
Volume 21, Issue 26 (12-2023)
Abstract
Introduction: The increase of iron due to aging affects the process of ferroptosis, and the final product of lipid peroxidation, MDA, is the central regulator of ferroptosis. Therefore, the aim of the research was to determine the effect of eight weeks of endurance training on the expression of GPX4 and MDA in the soleus muscle of aged male rats.
Materials and Methods: This study is of an experimental type. 20 healthy rats were divided into two groups of 10 each: training group and control group. The training was done incrementally for eight weeks. 48 hours after the last training session, the soleus muscle of mice was surgically removed and the amount of variables was measured by gene expression and ELISA methods.
Results: There was no significant difference in the level of GPX4 gene expression in the soleus muscle of exercise group rats compared to control group rats (p=0.4079). But the amount of MDA in the training group was significantly reduced compared to the control group (p=0.0028).
Conclusion: According to the findings of the present research, it seems that the effect of endurance training in this research shows a decrease in ferroptosis. The absence of a significant difference in the level of GPX4 gene expression is a sign that endurance training with this intensity does not affect it.
Elahe Talebi-Garakani, Shokoufeh Kheradmand, Khadijeh Nasiri,
Volume 21, Issue 26 (12-2023)
Abstract
The prevalence of obesity in postmenopausal women is higher compared to men. A decrease in estrogen with menopause leads to dysfunction in mitochondria. The purpose of this study is to investigate the effect of high intensity aerobic training(HIT) on the copy number of mitochondrial genome (mtDNAcn) and mitochondrial transcription factor A(Tfam) in visceral adipose tissue(VAT) in ovariectomized(OVX) rats fed with high-fat diet(HFD). 40 rats (8 weeks, 200±20 gr) were divided into 5 groups:1) normal diet (ND), 2) ND+OVX, 3) HFD, 4) HFD+OVX, and 5) HFD+OVX+HIT. HIT performed aerobic training (80-85% of maximum oxygen consumption) for 8 weeks/5 sessions/42 minutes.48 hours after the last training session, VAT samples were taken to evaluate mtDNAcn and Tfam gene expression by qRT-PCR method. ANOVA and LSD tests were used to compare the differences between groups. OVX and HFD didn’t lead to a significant change in Tfam gene expression, but caused a significant decrease in the mtDNAcn compared to the control group. HIT caused a significant increase in Tfam gene expression compared to the control group and Tfam gene expression and mtDNAcn compared to the HFD+OVX. Hence, HIT improves mitochondrial function through mtDNAcn and Tfam gene expression in VAT in OVX rats fed by HFD.
Javid Shah Hosseini, Arezoo Eskandari, Mohamad Fashi,
Volume 21, Issue 26 (12-2023)
Abstract
Using standard tests to assess maximum strength is very important where resistance training planning is based individually. This study aimed to estimate 1 repetition maximum of active women based on the Rating of Perceived and to provide a special predictive equation. 30 healthy women (20-35 years; BMI: 26.32 ± 3.34 kg/m2) performed one repetition of chest press with eyes close and then chose a number to determine the intensity by Rating of Perceived Exertion scale of 6-20. In order to evaluate the validity of the designed equation, one repetition of the maximum number of subjects was calculated by Brzycki equation, and correlation was determined by Pearson's correlation method. There was a high correlation between the present study equation and the Brzycki method (r=0.89) and also after cross validations (r=0.91). No significant difference was observed between the results of the present equation and the results of Berzyski's equation. It seems that the equation of the present study” 1RM={(20-RPE" /" 40) +1 }× weight/2 " can provide a reliable estimate for 1 repetition maximum of chest press in healthy women.
