Showing 3 results for Ravasi
Mr Hadi Habibi, Dr Ali Asghar Ravasi, Dr Neda Khaledi,
Volume 0, Issue 0 (11-2019)
Abstract
The impact of maternal physical activity on offspring health and phenotypic changes due to exercise has emerged as a significant area of interest in exercise physiology in recent years. Therefore, the aim of this study was to determine the effect of a maternal high-intensity interval training (HIIT) program on the expression of PGC1α and SIRT1 genes in the skeletal muscle of first-generation offspring in Wistar rats. Twenty-four 8-week-old female Wistar rats were acclimatized to the environment and then divided into three groups: a maternal control group, a maternal pre-pregnancy exercise group, and a maternal exercise group that trained both before and during pregnancy. The pre-pregnancy exercise regimen lasted 6 weeks, while the exercise during pregnancy lasted 3 weeks. The exercise protocol involved treadmill running, consisting of 5 days per week, with each session including 1 minute of running at 85-100% of VO2peak and a 10% incline, followed by 2 minutes of rest at 65% of VO2peak and 0% incline. The number of intervals started at 10 and increased based on the overload principle. The control group remained sedentary during this period. After the exercise period and the birth of the offspring, male offspring were categorized according to their maternal groups, and the expression levels of PGC1α and SIRT1 genes in their skeletal muscle were evaluated at 10 weeks of age. Data were analyzed using ANOVA and Tukey's post-hoc test.
The results indicated that after the 6-week HIIT program, both the pre-pregnancy exercise group and the group that exercised before and during pregnancy showed significant differences in speed and distance in the functional performance test compared to the control group (P < 0.05). Additionally, significant differences were observed in the expression of PGC1α and SIRT1 genes among the groups after the birth of the offspring. These differences were significant between the pre-pregnancy exercise group, the pre- and during-pregnancy exercise group, and the control group (P < 0.05). It appears that maternal exercise before and during pregnancy induces changes in the mitochondrial genotype of the offspring, with a more pronounced effect on the expression of mitochondrial genes such as PGC1α and SIRT1 when exercise occurs both before and during pregnancy compared to exercise before pregnancy alone.
Dr Elham Shirzad, Dr Ali Asghar Ravasi, Mojtaba Eshrestaghi,
Volume 13, Issue 9 (4-2015)
Abstract
Stiffness is an index for determination of elastic properties of body and its optimum range is different in various
motion patterns. The Spring-mass model is used for calculating stiffness. In this method, the whole leg is modeled
with a linear simple spring. The aim of this study is determination of lower body stiffness and evaluation of its
correlation with agility, as dominant motion pattern in racket sports. 12 national-level male racket-players (age:
25±4 years & weight: 80±7 kg) participated voluntarily in this study. Leg and vertical stiffness were measured
during running on treadmill and hopping test. Pearson’s correlation coefficients were used to examine the
relationships between stiffness and agility test records. Statistical significance was set at P< 0.05. There wasn’t
significant correlation with agility in this study. The reason could be of the contrast influence of knee and ankle
stiffness on performance. This problem requires separate evaluation of joint stiffness.
Dr Ali Asghar Ravasi, Dr Mousa Khalafi, Dr Karim Azali Alamdari,
Volume 19, Issue 22 (12-2021)
Abstract
Background and objective: Effects of exercise training on metabolic disorders through modifications in fibroblast growth factor -21 (FGF-21) level are controversial. Therefore, the aim of study was to determine the quantitative effect of exercise training protocols on serum FGF-21 level in adults with metabolic disorders. Methods: A systematic search of the published Persian or English-language studies from PubMed and Google Scholar databases up to march 2021 was done and standardized mean differences (SMDs) were calculated using random-effects models. Results: a total of 14 studies (aerobic training=3, resistance training=3, HIIT=4, concurrent training=4) including on 19 interventions conducted on 503 subjects (with overweight, obesity, type 2 diabetes, metabolic syndrome and or fatty liver disease) were eligible to include in the meta-analysis. However, because of the heterogeneity, the final quantitative impact of 16 interventions was calculated as a declining serum FGF21 level after training [SMD=-0.44(CI: -0.65 to -0.22) p=0.001] which had no correlation with subjects age(p=0.10) or BMI(p=0.50) level. Conclusion: exercise training protocols are efficient tools for a remarkable decrease in serum FGF-21 in patients with metabolic disorders which seems to lead to more beneficial effects on metabolic disturbances. However, more clinical trials are still warranted in this area considering the role of exercise components such as exercise intensity and type
