Dr Ali Barzegari, Dr Saeid Naghibi, Samaneh Safayi, Dr Mohammadhasan Dashti Khovidaki, Dr Anahita Salehi,
Volume 20, Issue 24 (3-2023)
Abstract
The purpose of this study was to compare two methods of aerobic exercise on the levels of SOD and TNF-α in the heart tissue of diabetic rats. 40 male Wistar rats aged ten weeks were randomly divided into four groups of 10: healthy control, diabetes, diabetes+MIT and diabetes+HIT. The moderate intensity training group ran 5 sessions per week for 8 weeks on the treadmill for 60 minutes at a speed of 25 meters per minute, and the high intensity training group also 5 sessions per week for 8 weeks with a training time of 60 minutes and at a speed of 34 meters per minute. The heart tissue of rats was examined to determine the amount of changes in SOD and TNF-α using ELISA method. To investigate the difference between groups of variables, one-way analysis of variance and Tukey's post hoc statistical tests were used at the significance level of P≥0.05. The results showed that there was a significant difference in the levels of TNF-α and SOD in the heart tissue of rats among the four research groups (P≤0.001). The levels of TNF-α in the HIT training group also showed a significant decrease compared to the diabetic group (P=0.001), While these changes in the MIT exercise group compared to the diabetes group was a non-significant decrease (P=0.117), the amount of SOD levels between the MIT and HIT exercise groups also showed a significant increase compared to the diabetic group (P=0.001). It seems, aerobic exercise with different intensities can improve SOD and TNF-α levels. Although the intensity of exercise in periodic exercise has been an effective factor in changing the values of both variables.
Mohsen Soltani, Ali Barzegari, Saeed Naghibi, Mohammad Hassaan Dashty Khavidaki,
Volume 21, Issue 26 (12-2023)
Abstract
This study aimed to investigate the effect of quercetin supplementation and training on myostatin and follistatin levels in the heart tissue of diabetic rats. Methods: For this purpose, 50 10-week-old male Wistar rats with an average weight of 237±33 grams were randomly divided into five groups of 10 including: healthy control, diabetes, diabetes+supplement, diabetes+exercise, and diabetes+supplement+exercise. . The training protocol includes five sessions per week for eight weeks on a treadmill without a special slope. The rodents ran for 60 minutes at a speed of 25 meters per minute in each session.and the supplement groups received 50 mg/kg quercetin daily by gavage. The results showed that the difference in myostatin levels among the groups is significant (P=0.001). There was a significant decrease in myostatin levels between exercise+supplement+diabetes group with diabetes (P=0.002). There was also a significant difference between the supplement+diabetes and exercise+diabetes groups (P=0.009). Also, the results showed that the difference in follistatin levels among the groups is significant (P=0.001). The results showed that follistatin levels in the heart tissue increased significantly between the groups of diabetes, exercise+diabetes, supplement+diabetes and exercise+supplements+diabetes with the control group (respectively: P=0.005; P=0.001; P=0.001; P = 0.001).
It seems that moderate intensity aerobic exercise and quercetin supplementation have a positive and beneficial effect on the levels of myostatin and folstatin.
Azam Davoodabadi, Saeed Naqeibi, Ali Barzegari, Mohammad Hassaan Dashty Khavidaki,
Volume 22, Issue 27 (8-2024)
Abstract
The aim of this study was the effect of a course of aerobic exercises on depression and oxidative stress factor changes in the hippocampus and prefrontal cortex of rats with Alzheimer's disease. For this purpose, 40 8-week-old male Wistar rats with an average weight of 237±33 grams were randomly divided into four groups of 10: control, exercise, Alzheimer's, and exercise+Alzheimer's. The training protocol consisted of 12 weeks of running on a treadmill at a speed of 12 meters per minute and for 30 minutes in each session. At the end of the training period, the tests of feeding sensation suppression and tail suspension were performed to estimate depression as well as hippocampal and prefrontal malondialdehyde levels using the Bradford method. Also, in order to induce Alzheimer's, an amount of three mg/kg of streptozocin in a volume of five microliters of sterile distilled water was injected into the ventricle of the brain. The results showed that exercise training caused a significant decrease in depression in eating delay tests and immobility duration in Alzheimer's rats. Also, exercise caused a significant decrease in malondialdehyde levels in the hippocampus of Alzheimer's rats, while a significant difference was observed in the prefrontal area. It didn't happen. It seems that sports activity creates immunity against Alzheimer's and is probably effective in preventing depression in Alzheimer's patients.
