دوره 22، شماره 27 - ( 6-1403 )
جلد 22 شماره 27 صفحات 74-55 |
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Ahmadi E, Shahrbanian S, Kordi M, Gharakhanlou R, Pearcey G. The Effect Of Swimming Aerobic Training On The Levels Of IL-6 And IL-10 In The Brain Tissue Of Female Mice With Experimental Autoimmune Encephalomyelitis. RSMT 2024; 22 (27) :55-74
URL: http://jsmt.khu.ac.ir/article-1-605-fa.html
URL: http://jsmt.khu.ac.ir/article-1-605-fa.html
احمدی المیرا، شهربانیان شهناز، کردی محمدرضا، قراخانلو رضا، پیرسی گریگوری. تأثیر تمرین هوازی شنا بر سطوح IL-6 و IL-10 در بافت مغز موش‌های ماده مبتلا به انسفالومیلیت خودایمن تجربی. پژوهش در طب ورزشی و فناوری. 1403; 22 (27) :55-74
دانشیار، گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه تربیت مدرس، تهران- ایران. ، sh.shahrbanian@modares.ac.ir
چکیده: (3519 مشاهده)
خستگی از شکایات بیماران مالتیپل اسکلروزیس (MS) است. در بیماران MS تعادل سایتوکاین‌های التهابی در مغز برهم ریخته که یکی از رخدادهای آن خستگی ذهنی است و احتمالاً تمرینات هوازی میزان التهاب سایتوکاین‌ها را تعدیل کرده و از این طریق خستگی ذهنی را کاهش می‌دهد. مطالعه حاضر به منظور بررسی تأثیر تمرین هوازی شنا بر فاکتور پیش التهابی (اینترلوکین 6) و فاکتور ضدالتهابی (اینترلوکین 10) برای ارزیابی خستگی ذهنی در مغز موش‌های ماده پس از القای EAE انجام شد. در این پژوهش 21 موش (8 هفته‌ای، 18 تا 20 گرم) به 3 گروه کنترل سالم، کنترل EAE و فعالیت ورزشی هوازی شنا EAE تقسیم شدند و حیوانات در گروه تمرین طی 4 هفته، هرهفته 5 جلسه‌ی 30 دقیقه‌ای به تمرینات شنا با شدت متوسط پرداختند. بررسی آزمایشگاهی متغیرهای پژوهش با روش وسترن بلات انجام شد. نتایج نشان داد در میزان IL-6 در میان گروه EAE و تمرین شنا تفاوت معناداری وجود نداشت اما میزان IL10 در گروه تمرین شنا نسبت به گروه EAE افزایش معنی داری نشان داد. با این حال نسبت مقادیر IL10/IL6 بین گروه تمرین شنا با EAE نیز معنادار نبود. بنظر می‌رسد تمرینات هوازی شنا با شدت متوسط، بدون تغییر در عامل پیش التهابی، همراه با سوق دادن به سمت عوامل ضدالتهابی، با افزایش IL10، می‌تواند بین گروه EAE و تمرین شنا منجر به بهبود تعادل شاخص التهابی و کاهش میزان خستگی ذهنی ناشی از خستگی سایتوکاینی گردد.
نوع مطالعه: كاربردي |
موضوع مقاله:
فیزیولوژی ورزشی
دریافت: 1402/3/16 | پذیرش: 1402/10/13 | انتشار: 1403/6/10
دریافت: 1402/3/16 | پذیرش: 1402/10/13 | انتشار: 1403/6/10
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