The Effect Of A Period Of Aerobic Exercises On Of Depression And Changes The Oxidative Stress In The Hippocampus And Prefrontal

Davoodabadi, Azam; Naqeibi, Saeed; Barzegari, Ali; Dashty khavidaki, mohammad hassaan

doi:10.61186/jsmt.22.27.34

Volume 22, Issue 27 (8-2024) RSMT 2024, 22(27): 34-54 | Back to browse issues page

‎ 10.61186/jsmt.22.27.34

Mendeley

Zotero

RefWorks

Davoodabadi A, Naqeibi S, Barzegari A, Dashty khavidaki M H. The Effect Of A Period Of Aerobic Exercises On Of Depression And Changes The Oxidative Stress In The Hippocampus And Prefrontal. RSMT 2024; 22 (27) :34-54
URL: http://jsmt.khu.ac.ir/article-1-535-en.html

The Effect Of A Period Of Aerobic Exercises On Of Depression And Changes The Oxidative Stress In The Hippocampus And Prefrontal

Azam Davoodabadi

, Saeed Naqeibi

, Ali Barzegari

, Mohammad hassaan Dashty khavidaki

Associate Professor, Department of Physical Education and Sports Sciences, Payam Noor University, Tehran, Iran. , ali_barzegari_1014@yahoo.com

Abstract: (3031 Views)

The aim of this study was the effect of a course of aerobic exercises on depression and oxidative stress factor changes in the hippocampus and prefrontal cortex of rats with Alzheimer's disease. For this purpose, 40 8-week-old male Wistar rats with an average weight of 237±33 grams were randomly divided into four groups of 10: control, exercise, Alzheimer's, and exercise+Alzheimer's. The training protocol consisted of 12 weeks of running on a treadmill at a speed of 12 meters per minute and for 30 minutes in each session. At the end of the training period, the tests of feeding sensation suppression and tail suspension were performed to estimate depression as well as hippocampal and prefrontal malondialdehyde levels using the Bradford method. Also, in order to induce Alzheimer's, an amount of three mg/kg of streptozocin in a volume of five microliters of sterile distilled water was injected into the ventricle of the brain. The results showed that exercise training caused a significant decrease in depression in eating delay tests and immobility duration in Alzheimer's rats. Also, exercise caused a significant decrease in malondialdehyde levels in the hippocampus of Alzheimer's rats, while a significant difference was observed in the prefrontal area. It didn't happen. It seems that sports activity creates immunity against Alzheimer's and is probably effective in preventing depression in Alzheimer's patients.

Keywords: Alzheimer, Hippocampus, prefrontal, Streptozocin, Malondialdehyde

Full-Text [PDF 2389 kb] (272 Downloads)

Type of Study: Research | Subject: sport physiology
Received: 2023/05/21 | Accepted: 2023/12/1 | Published: 2024/08/31

References

1. Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature. 2010:529-35. DOI: 10.1038/nature08983. [DOI:10.1038/nature08983]

2. Yirmiya R, Goshen I. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun. 2011;25(2):181-213. DOI: 10.1016/j.bbi.2010.10.015 [DOI:10.1016/j.bbi.2010.10.015]

3. Fernández M, Gobartt AL, Balañá M. Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment. BMC Neurol. 2010;10(1):1-9. DOI: 10.1186/1471-2377-10-87 [DOI:10.1186/1471-2377-10-87]

4. Nazem A, Sankowski R, Bacher M, Al-Abed Y. Rodent models of neuroinflammation for Alzheimer's disease. Journal of neuroinflammation. 2015;12(1):1-15. DOI: 10.1186/s12974-015-0291-y [DOI:10.1186/s12974-015-0291-y]

5. Prasansuklab A, Tencomnao T, Medicine A. Amyloidosis in Alzheimer's disease: the toxicity of amyloid beta (Aβ), mechanisms of its accumulation and implications of medicinal plants for therapy. Evid Based Complement Alternat Med. 2013;2013. DOI: 10.1155/2013/413808 [DOI:10.1155/2013/413808]

6. Benilova I, Karran E, De Strooper B. The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nature neuroscience. 2012;15(3):349-57. DOI: 10.1038/nn.3028 [DOI:10.1038/nn.3028]

7. Lee S-Y, Lee S-J, Han C, Patkar AA, Masand PS, Pae C-U. Oxidative/nitrosative stress and antidepressants: targets for novel antidepressants. Prog Neuropsychopharmacol Biol Psychiatry. 2013;46:224-35. DOI: 10.1016/j.pnpbp.2012.09.008 [DOI:10.1016/j.pnpbp.2012.09.008]

8. Shelat PB, Chalimoniuk M, Wang JH, Strosznajder JB, Lee JC, Sun AY, et al. Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons. Journal of neurochemistry. 2008;106(1):45-55. DOI: 10.1111/j.1471-4159.2008.05347.x [DOI:10.1111/j.1471-4159.2008.05347.x]

9. Pitts A, Dailey K, Newington JT, Chien A, Arseneault R, Cann T, et al. Dithiol-based compounds maintain expression of antioxidant protein peroxiredoxin 1 that counteracts toxicity of mutant huntingtin. Journal of Biological Chemistry. 2012;287(27):22717-29. DOI: 10.1074/jbc.M111.334565 [DOI:10.1074/jbc.M111.334565]

10. Parajuli B, Sonobe Y, Horiuchi H, Takeuchi H, Mizuno T, Suzumura A, et al. Oligomeric amyloid β induces IL-1 β processing via production of ROS: implication in Alzheimer's disease. Cell death. 2013;4(12):e975-e. DOI: 10.1038/cddis.2013.503 [DOI:10.1038/cddis.2013.503]

11. Ardakani-zadeh M, Vesali-akbarpour L. Comparison of the effects of 10 weeks mid and long-term swimming induced oxidative stress on left ventricular angiogenesis in male rats. Journal of Sport Exercise Physiology. 2021;14(1):119-30. DOI: 10.52547/JOEPPA.14.1.119. [In Persian] [DOI:10.52547/joeppa.14.1.119]

12. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry cell biology. 2007;39(1):44-84. DOI: 10.1016/j.biocel.2006.07.001 [DOI:10.1016/j.biocel.2006.07.001]

13. Donzis EJ, Tronson NC. Modulation of learning and memory by cytokines: signaling mechanisms and long term consequences. Neurobiology of learning memory. 2014;115:68-77. DOI: 10.1016/j.nlm.2014.08.008 [DOI:10.1016/j.nlm.2014.08.008]

14. Cassilhas RC, Tufik S, de Mello MT. Physical exercise, neuroplasticity, spatial learning and memory. Cellular molecular life sciences. 2016;73(5):975-83. DOI: 10.1007/s00018-015-2102-0 [DOI:10.1007/s00018-015-2102-0]

15. Qomi MS, Kashif M, Salehpour M. The effect of eight weeks resistance and endurance training on some angiogenesis factors of hippocampus tissue in male wistar rats. Journal of Sport Exercise Physiology. 2021;14(2/45):54. DOI:10.52547/JOEPPA.14.2.45. [In Persian] [DOI:10.52547/joeppa.14.2.45]

16. Antunes H, De Mello M, Santos-Galduróz R, Galduróz J, Lemos VA, Tufik S, et al. Effects of a physical fitness program on memory and blood viscosity in sedentary elderly men. Brazilian Journal of Medical Biological Research. 2015;48:805-12. DOI: 10.1590/1414-431X20154529 [DOI:10.1590/1414-431x20154529]

17. Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory. Proceedings of the national academy of sciences. 2011;108(7):3017-22. DOI: 10.1073/pnas.1015950108 [DOI:10.1073/pnas.1015950108]

18. Um HS, Kang EB, Cho IH, Kim CH, Cho JS, Hwang DY. The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice. International journal of molecular medicine. 2010;25(3):337-46. DOI: 10.3892/ijmm_00000350 [DOI:10.3892/ijmm_00000350]

19. Wolf SA, Kronenberg G, Lehmann K, Blankenship A, Overall R, Staufenbiel M, et al. Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease. Biological psychiatry. 2006;60(12):1314-23. DOI: 10.1016/j.biopsych.2006.04.004 [DOI:10.1016/j.biopsych.2006.04.004]

20. Hosseinzadeh S, Dabidi Roshan V, Mahjoub S, Taghipour Darzi M. The interactive effect of lead acetate and endurance training on the brain-derived neurotrophic factor and malondialdehyde levels in rats cortex. Journal of babol university of medical sciences. 2012;14(2):7-15. [In Persian]

21. Bazyar Y, Rafiei S, Hosseini A, Edalatmanesh MA. Effect of Endurance Exercise Training and Gallic Acid on Tumor Necrosis Factor-α in an Animal Model of Alzheimer's Disease. The Neuroscience Journal of Shefaye Khatam. 2015;3(3):21-6. DOI: 10.18869/acadpub.shefa.3.3.21. [In Persian] [DOI:10.18869/acadpub.shefa.3.3.21]

22. Gu Y, Dee CM, Shen J. Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability. Front Biosci. 2011;3(3):1216-31. DOI: 10.2741/222 [DOI:10.2741/222]

23. Knapp LT, Klann E. Role of reactive oxygen species in hippocampal long‐term potentiation: contributory or inhibitory? Journal of neuroscience research. 2002;70(1):1-7. DOI: 10.1002/jnr.10371 [DOI:10.1002/jnr.10371]

24. Shahidi S, Sadeghian R, Komaki A, Asl SS. Intracerebroventricular microinjection of the 5-HT1F receptor agonist LY 344864 inhibits methamphetamine conditioned place preference reinstatement in rats. Pharmacology Biochemistry Behavior. 2018;173:27-35. DOI: 10.1016/j.pbb.2018.08.001. [In Persian] [DOI:10.1016/j.pbb.2018.08.001]

25. Juszczyk G, Mikulska J, Kasperek K, Pietrzak D, Mrozek W, Herbet M. Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and treatment. Antioxidants. 2021;10(9):1439. DOI: 10.3390/antiox10091439 [DOI:10.3390/antiox10091439]

26. Valenzuela PL, Castillo-García A, Morales JS, de la Villa P, Hampel H, Emanuele E, et al. Exercise benefits on Alzheimer's disease: State-of-the-science. Ageing research reviews. 2020;62:101108. DOI: 10.1016/j.arr.2020.101108 [DOI:10.1016/j.arr.2020.101108]

27. Larun L, Nordheim LV, Ekeland E, Hagen KB, Heian F. Exercise in prevention and treatment of anxiety and depression among children and young people. Cochrane database of systematic reviews. 2006(3). DOI: 10.1002/14651858.CD004691.pub2 [DOI:10.1002/14651858.CD004691.pub2]

28. Deslandes A, Moraes H, Ferreira C, Veiga H, Silveira H, Mouta R, et al. Exercise and mental health: many reasons to move. Neuropsychobiology. 2009;59(4):191-8. DOI: 10.1159/000223730 [DOI:10.1159/000223730]

29. Sleiman SF, Henry J, Al-Haddad R, El Hayek L, Abou Haidar E, Stringer T, et al. Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. Elife. 2016;5:e15092. DOI: 10.7554/eLife.15092 [DOI:10.7554/eLife.15092]

30. Wu C, Yang L, Li Y, Dong Y, Yang B, Tucker LD, et al. Effects of Exercise Training on Anxious-Depressive-like Behavior in Alzheimer Rat. Medicine science in sports exercise. 2020;52(7):1456. DOI: 10.1249/MSS.0000000000002294 [DOI:10.1249/MSS.0000000000002294]

31. Jafarzadeh G, Shakeryan S, Farbood Y, Ghanbarzadeh M. Effect of One Session of Resistance Exercises on Expression of BDNF Gene and TrkB Receptor in Alzheimer Model Male Wistar Rats. Journal of Fasa University of Medical Sciences. 2019;8(4):1167-76. ‎ DOI: 20.1001.1.22285105.2019.8.4.17.3. [In Persian].

32. Alyari N, Vahdatpour T, Karami-bonari A. Effects of Swim Training on Inflammatory Factors and Oxidative Stress of Kidneys in Diabetic and Ovariectomized Female Rats. Journal of Applied Exercise Physiology. 2020;16(31):89-103. DOI: 10.22080/JAEP.2020.18101.1928 . [In Persian].

33. Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiological reviews. 2008;88(4):1243-76. DOI: 10.1152/physrev.00031.2007 [DOI:10.1152/physrev.00031.2007]

34. Seifi Nahavandi B, Yaghmaei P, Ahmadian S, Ebrahim-Habibi A, Ghobeh M. Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer's Disease among Rats. Qom University of Medical Sciences Journal. 2020;14(10):25-33. DOI:‎ 10.52547/qums.14.10.25. [In Persian]. [DOI:10.52547/qums.14.10.25]

35. Hassanshahi J, Rahmani M, Shibani F, Kaeidi A. The Oleuropein Effect on Neurotrophic Factor Expression Level in Hippocampal Tissue and Memory Defect Induced by Morphine in Male Rats: An Experimental Study. J Rafsanjan Univ Med Sci. 2020;19(9):969-78. DOI:‎ 10.29252/jrums.19.9.969 ‎ 20.1001.1.17353165.1399.19.9.3.2 . [In Persian]. [DOI:10.29252/jrums.19.9.969]

36. Mahdavi R, Naghibi S, Barzegari A. The Effect of a Course of Swimming and Minocycline Exercises After Childhood Infection on Anxiety and Malondialdehyde Levels in the Hippocampus and Peripheral Cortex of NMRI Mice. Journal of Sport Biosciences. 2022;14(4):65-51. DOI:‎ 10.22059/jsb.2023.352436.1562 . [In Persian].

37. Maciel AL, Abelaira HM, de Moura AB, de Souza TG, Rosa T, Matos D, et al. Acute treatment with ketamine and chronic treatment with minocycline exert antidepressant-like effects and antioxidant properties in rats subjected different stressful events. Brain Research Bulletin. 2018;137:204-16. DOI: 10.1016/j.brainresbull.2017.12.005 [DOI:10.1016/j.brainresbull.2017.12.005]

38. Halliwell B, aging. Role of free radicals in the neurodegenerative diseases. Drugs. 2001;18(9):685-716. DOI: 10.2165/00002512-200118090-00004. [DOI:10.2165/00002512-200118090-00004]

39. Mohammadi M, Salehi I, Farajnia S. Effect of Swimming Exercise on Oxidative Stress in Hippocampus of Diabetic Male Rats. Medical Journal of Tabriz University of Medical Sciences. 2008;30(2):111-8. https://mj.tbzmed.ac.ir/Article/6246. [In Persian].

40. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends in neurosciences. 2002;25(6):295-301. DOI: 10.1016/s0166-2236(02)02143-4. [DOI:10.1016/S0166-2236(02)02143-4]

41. Hosseinzadeh S, Dabidi Roshan V. Effects of Curcumin supplementation on BDNF and Oxidative/antioxidative process in rat's hippocampus which exposed to lead. Journal of Gorgan University of Medical Sciences. 2011;13(2):1-8. http://goums.ac.ir/journal/article-1-1058-en.html. [In Persian].

42. Radak Z, Chung HY, Koltai E, Taylor AW, Goto S. Exercise, oxidative stress and hormesis. Ageing research reviews. 2008;7(1):34-42. DOI: 10.1016/j.arr.2007.04.004. [DOI:10.1016/j.arr.2007.04.004]

43. Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: friend or foe? Journal of sport health science. 2020;9(5):415-25. DOI: 10.1016/j.jshs.2020.04.001. [DOI:10.1016/j.jshs.2020.04.001]