دوره 19، شماره 22 - ( 10-1400 )
جلد 19 شماره 22 صفحات 54-37 |
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alabaf yousefi F, pouzesh jadidi R, Bashiri J, Vakili J. Effects of HIIT and Curcumin Supplementation on Rat Cardiac Fibrosis Signaling Pathway Following Myocardial Infraction. RSMT 2021; 19 (22) :37-54
URL: http://jsmt.khu.ac.ir/article-1-477-fa.html
URL: http://jsmt.khu.ac.ir/article-1-477-fa.html
اعلاباف یوسفی فریده، پوزش جدیدی رقیه، بشیری جبار، آزالی علمداری کریم، وکیلی جواد. اثرات تمرین تناوبی شدید و مکمل کورکومین بر پیام‌رسانی مسیر فیبروز قلبی موش‌های صحرایی متعاقب سکته قلبی. پژوهش در طب ورزشی و فناوری. 1400; 19 (22) :37-54
دانشگاه آزاد اسلامی تبریز ، Poozesh@iaut.ac.ir
چکیده: (3462 مشاهده)
هدف: هدف تحقیق تأثیر 12 هفته تمرین تناوبی شدید (HIIT) به همراه مصرف کورکومین بر مقدار بیان FSTL1، Smad7 و کلاژن‌های نوع I، III و IV بطن چپ موش‌های صحرایی نر مدل سکته قلبی بود. روش‌شناسی: پس از القای سکته قلبی، 48 سر موش صحرائی به پنج گروه: مرجع، تمرین، کورکومین، توأم (تمرین+کورکومین) و کنترل تقسیم شدند. پس از کشتار گروه مرجع برای تأیید بروز سکته، کورکومین روزانه 15 میلی‌گرم به ازای هر کیلوگرم وزن بدن به صورت گاواژ استفاده شد. جلسات تمرین HIIT پنج روز در هفته، هر جلسه شامل 60 دقیقه متشکل از 10 وهله (هر وهله چهار دقیقه) دویدن با شدت 90-85 درصد از vVO2 peak با دو دقیقه فاصله استراحت فعال در بین تکرارهای دویدن با شدت 50-45 درصد از vVO2 peak برگزار شدند. مقدار بیان پروتئین‌های FSTL1، Smad7 و همچنین کلاژن‌های I، III و IV بافت بطن چپ توسط وسترن بلات اندازه‌گیری شدند. یافته‌ها: پس از هر سه مداخله شامل تمرین، کورکومین و توأم، وزن قلب به‌طور معنی‌داری بیشتر (به ترتیب 001/0=P، 018/0=P و 001/0=P) و مقدار بیان کلاژن نوع IV کمتر (001/0=P در هر سه مورد) از گروه کنترل بودند. فقط در گروه توأم مقدار بیان کلاژن نوع III قلب به‌طور معنی‌داری کمتر (033/0=P) و FSTL و Smad7 (001/0=P) و Smad7 (008/0=P) بیشتر از گروه کنترل بود. نتیجه‌گیری: کاهش کلاژن نوع IV بدون مرگ‌ومیر در اثر اعمال هر سه مداخله، شاید به ایمن بودن تمرین HIIT و مکمل کورکومین برای کاهش روند فیبروز قلبی متعاقب سکته دلالت کند؛ اما فقط مداخله توأم سبب کاهش بیان پروتئین کلاژن نوع III و افزایش FSTL و Smad7 در بطن چپ دچار سکته شد که زمینه تجویز توأم کورکومین و HIIT برای کسب نتایج بهتر را فراهم می‌کند؛ اما به دلیل محدودیت‌های تحقیق و کمبود شواهد انسانی، همچنان نیاز به تحقیقات بیشتر باقی است.
نوع مطالعه: پژوهشي |
موضوع مقاله:
فیزیولوژی ورزشی
دریافت: 1399/12/5 | پذیرش: 1400/5/25 | انتشار: 1400/10/1
دریافت: 1399/12/5 | پذیرش: 1400/5/25 | انتشار: 1400/10/1
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