Showing 2 results for Cancer
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Volume 9, Issue 4 (10-2010)
Abstract
The Ursolic Acid and Oleanolic Acid presented in apple peels have a potential antioxidant acivity. Antiprolifertive acivity of the triterpenoids against human liver cancer cells, breast cancer cells and colon cancer ells is evaluated. In this study, we have used Ursolic Acid and Oleanolic Acid which are predominant isolated triterpenoids of the apple peels.. The purpose of this study is to determine antimutation and anticarcinogen effect of Ursolic Acid and Oleanolic Acid against Sodium Azide mutagen substance by the use of Microsome and Ames test.
These substances were white powder and soluble in Acetone and bought from sigma company. The bacterium used in this test is a strain of Salmonella thyphimurium (TA100) that carries a selective mutation in its Histidine Operon. We also added Microsome to improve anticancer activity of this two triterpenoids. In this study, inhibition percentage from mutation was 83% for ursolic acid and 76.4 % for oleanolic acid in presence of Microsome ( and 77.6 % for Ursolic Acid and 69.8 % for Oleanolic Acid in absence of Microsome) . Therefore , presence of anti mutation Ursolic Acid and oleanolic acid along with mutagen substance, reduced quantity of back mutation and Inhibition over 40 % recommended as a powerful antimutation substance. Therefore, apple peel has large amount of active Phytochemicals, with Antimutation and Anticarcinogen activity and Ursolic Acid has more antimutation activity than Oleanolic acid
Volume 18, Issue 51 (5-2005)
Abstract
Long-term UVB and UVC irradiation can increase the skin cancer risk the researchers insist more on the carcinogenetic effect of UVB, but scale cells cancer of skin and malignant melanoma are caused by UVA radiation. Regard to broad use of UV (260nm) lamps in laboratory hoods, it is necessary to study the effect of UVC (260 nm) radiation on the skin. In this study, the effect of UVC radiation with wavelenght 260 nm on the skin and ear of one month and two months old Balb/c mice during 25, 50, and 100 hours exposure time have been investigated. The results show that UV (260nm) radiation increases the epidermis thickness. The other skin layers in both ages show alternate changes in different exposure times. Also, it may be concluded that the increase in hair follicles is not significant.
