Salman Rahmani,
Volume 11, Issue 3 (2-2011)
Abstract
An efficient, mild and environmentally- friendly approach was developed for the synthesis of bis arylidine cycloalkanones. SnCl4 was found as efficient catalyst for cross aldol condensation of cycloalkanones and aromatic aldehyde for synthesis of &alpha,&alpha'-bis(substituted-benzylidine) cycloalkanones in ethanol as a green solvent. In this method, the reaction works easily for a variety of aldehydes with both electron-donating and electron-with-drawing groups to give corresponding &alpha,&alpha’-bis(substituted-benzylidene) cyclohexanones in good to excellent yields. Comparing the known methods, the main advantages of our method are short time, user-friendly, low cost procedure, clean and environmentally benign reagents with ease of separation of the product and mild reaction condition with good to excellent yield for products
