Volume 9, Issue 1 (10-2010)
2010, 9(1): 59-68 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Synthesis of 1,8-dioxo-octahydroxanthene derivatives using NBS under mild conditions. Journal title 2010; 9 (1) :59-68
URL: http://jsci.khu.ac.ir/article-1-1335-en.html
URL: http://jsci.khu.ac.ir/article-1-1335-en.html
Abstract: (5027 Views)
An efficient one-pot synthesis of 1,8-dioxo-octahydroxanthene is achieved through a condensation of arylaldehydes and 5,5-dimethyl-1,3-cyclohexanedione in the presence of N-bromosuccinimid. This method enjoys several advantages such as low cost, simple work up procedure and safe reaction conditions. Graphical Abstract Table 1. Optimization of reaction condition. Entry Amount of NBS Condition Yield (%)a 1 0 mol % Reflux/ethanol/20 h 0 2 2 mol % 50°C/ethanol/12 h tr 3 2 mol % Reflux/ethanol/14 h 15 4 5 mol % Reflux/ethanol/14 h 30 5 10 mol % Reflux/ethanol/14 h 55 6 15 mol % Reflux/ethanol/14 h 80 7 20 mol % Reflux/ethanol/14 h 94 8 20 mol % MW/DMAC/5 min 90 a Isolated yield.
Type of Study: S |
Published: 2010/10/15
Published: 2010/10/15
| Rights and permissions | |
 | This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
