Volume 8, Issue 1 (صفحات انگلیسی از 1 تا 6(چکیده) 2009)
2009, 8(1): 21-30 |
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Teratogenic effects of Tolualdoxime on the Spermatogenesis of mature Balb/C mice. Journal title 2009; 8 (1) :21-30
URL: http://jsci.khu.ac.ir/article-1-1221-en.html
URL: http://jsci.khu.ac.ir/article-1-1221-en.html
Abstract: (4774 Views)
Oxime is an important functional group in organic chemistry which can protect carboxilic groups and are applied as insecticides, fungicide and acaricides. It has been reported that some members of oxime family decrease spermatogenesis and oogenesis. Due to the similar structure of tolualdoxime with other oximes, in this study we evaluated the effects of tolualdoxime on spermatogenesis in order to achieve a male contraceptive compound with minimum side effects. LD50 standard was found 350 mg/kg B.W. In this research mature mice received 175 mg/kg /B.W. a daily single dose for two weeks .The analysis of results showed significant decrease in different parameters (p<0.05) in the experimental group compared with the controls. The results observed are as follows: decrease in body weight and the number of spermatogonia, primary spermatocyts, spermatids and sperms. In addition, in some experimental groups, spermatid cysts and release of primary spermatocytes, and spermatids into the lumen of seminiferous tubules were observed.
Published: 2009/12/15
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