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Providing, maintaining and improving health of infants as a vulnerable group has a special place in health care. Due to the importance of this index in the United Nations development indices, we compared the socioeconomic determinants of infant mortality rate in Iran and MENA countries during 1980- 2010. The aims of this comparison was to determine major causes of inequalities in infant mortality rate in the region and also to determine why this index is very high and very low in different countries..