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Transportation has been one of the human primary needs and it has been found a wider range with the economic and social development, today it’s considered as a symbol of civilization. It is one of the infrastructure sections in every society that, it not only influences on the development process but also will be changed during development. So, this study investigated the effect of transportation infrastructure on economic growth in some of Iran's provinces by using of panel data model and data from 2000 to 2011. The results indicate that transportation infrastructure as a variable had a positive effect on economic growth. Moreover, provinces that had more populations could help the promotion of the economic growth by changing the underlying structures such as the transportation capacity and the quality of the transportation systems.