'space economy' It is the general theory of locating all economic activities in which the geographical distribution of inputs (Intermediate or production factors) and geographical distribution of output (intermediate and final consumption markets), Along with spatial changes, prices and costs are considered. In this concept, the general equilibrium approach in terms of transportation costs and distance is suggested for economic analysis.. Due to the fact that in this approach, several factors influence the creation of balance. The aim of the current research is to model the factors affecting the economy of space in Iranian metropolises (Tehran, Karaj, Qom, Isfahan, Mashhad, Shiraz, Tabriz and Ahvaz) using the Markov switching panel approach. Based on the results of provincial added value; public investment; Higher education as a representative of the knowledge economy in the province and the share of the urban population, which indicates the degree of industrialization of the examined cities had a positive effect on investment in space, and the variables of the share of old age in the total population of the province and inflation had a negative effect on investment in this variable; Also, based on the results of the major research on investment in the field of space in the big cities of Iran except Tehran and Karaj in recent years, which coincides with the boom years in the estimation model; It has been done.