This study aimed to examine structural relationship between the structure of parental meta-emotion (guiding and awareness) and academic adjustment through the mediation of differentiation. For this study, 241 undergraduate students of Shiraz University are selected by single stage cluster sampling. Valid three scales: scale view of parenting meta-Sweeney Bourne (SMEPS), short form their differentiation (DSI-SE), and academic adjustment scale "California Personality Inventory" are employed. Path analysis via regression is used for data analysis. Amos software is utilized to assess the significance of mediating and model fit. Results showed that model is a good fit to the data, and as well guiding the awareness through the mediation of differentiation, predicted academic adjustment to be indirect and more powerful than the direct route.